Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance in Mycobacterium tuberculosis

Molecular and Cellular Probes
P DobnerH Rinder

Abstract

Specific mutations associated with resistance to streptomycin (SM) in Mycobacterium tuberculosis suggest themselves for its rapid prediction. However, as with any diagnostic test, their predictive values are dependent on their prevalences. In this report, SM resistance associated mutations in the rrs and rpsL genes of 25 SM resistant isolates from Germany and 25 SM resistant isolates from Sierra Leone were characterized and compared. Mutations in the rrs gene were infrequent in isolates from both localities (20% and 12%, respectively) and thus of limited predictive values. In contrast, rpsL mutations were found in 48% of the German isolates but only in 24% of the isolates from Sierra Leone. It is concluded that the predictive values of mutations in this gene may vary significantly with the origin of the samples under investigation.

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Citations

Aug 31, 2010·The Journal of Antimicrobial Chemotherapy·Griselda TudóJulià González-Martín
Aug 26, 2003·Antimicrobial Agents and Chemotherapy·Annika KrüünerSven Hoffner
May 10, 2013·Journal of Clinical Microbiology·Beatriz E FerroDick van Soolingen
Jan 9, 2004·Clinics in Laboratory Medicine·Harri J Marttila, Hanna Soini
Mar 1, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·T C VictorR Warren
Jun 13, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y-J SunA S G Lee
Aug 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicholas F MarkoValerie W Hu
Feb 11, 2005·Chemical Reviews·Sophie Magnet, John S Blanchard

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