PMID: 9438470Jan 23, 1998Paper

Geographical and seasonal association between linamarin and cyanide exposure from cassava and the upper motor neurone disease konzo in former Zaire

Tropical Medicine & International Health : TM & IH
J P Banea-MayambuH Rosling

Abstract

High cyanide intake from consumption of insufficiently processed cassava has been advanced as a possible aetiology of the upper motor neurone disease konzo. However, similar neurodamage has not been associated with cyanide exposure from any other source. With an ecological study design, we compared 22 cases of konzo, 57 unaffected household members and 116 members from unaffected households, a total of 195 subjects, in konzo-affected savanna villages with 103 subjects in adjacent non-affected forest villages in the Paykongila area in the Bandundu Region, Zaire. In the dry season, the mean value (+/- SEM) of urinary thiocyanate, the main cyanide metabolite, was higher in the three groups in konzo-affected villages (563 +/- 105, 587 +/- 44 and 629 +/- 47 micromol/l) than in unaffected villages (241 +/- 17 micromol/l). In affected villages in the dry season when konzo incidence was high, mean urinary thiocyanate was also higher than the levels found in the wet season when incidence was low. The wet season values (mean +/- SEM) were 344 +/- 60, 381 +/- 35 and 351 +/- 27 micromol/l. Urinary levels of inorganic sulphate were low in all groups, indicating low intake of the sulphur amino-acids which provide a substrate for cyanide deto...Continue Reading

Citations

May 1, 2005·Environmental Toxicology and Pharmacology·Jean-Claude MwanzaThorkild Tylleskär
Jul 9, 2011·PLoS Neglected Tropical Diseases·Hipólito Nzwalo, Julie Cliff
Feb 1, 2014·Metabolic Brain Disease·G M BumokoD D Tshala-Katumbay
Jan 10, 2012·Current Opinion in Biotechnology·Elisa Leyva-GuerreroRichard T Sayre
Aug 10, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J N ChabwineB Nemery
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Jun 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jordi LlorensPere Boadas-Vaello
Mar 1, 1997·Lancet·M BaneaH Rosling
Feb 7, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S KimaniD Tshala-Katumbay
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