PMID: 287049May 1, 1979Paper

Geometric and electronic structure of oxyhemocyanin: spectral and chemical correlations to met apo, half met, met, and dimer active sites

Proceedings of the National Academy of Sciences of the United States of America
N C EickmanEdward I. Solomon

Abstract

The chemical and spectral properties of a series of hemocyanin derivatives were systematically compared to provide insight into the geometric and electronic structure of the oxyhemocyanin active site. The binuclear copper site is characterized as two tetragonal Cu(II) atoms bridged by both an endogenous protein ligand and the exogenous ligand (i.e., peroxide), with the lack of an electron paramagnetic resonance signal being the result of antiferromagnetic exchange via the endogenous bridge. A transition dipole-vector coupling model is used to assign the unique absorption spectral properties of oxyhemocyanin: the bands at 570 and 486 nm are assigned as components of the peroxide pi v* to copper dx2-y2 charge transfer. The 345-nm band is one component of the pi sigma* leads to dx2-y2 charge transfer. The model also predicts an end-to-end bridging geometry for the peroxide in oxyhemocyanin.

References

Mar 15, 1978·Biochemical and Biophysical Research Communications·R S HimmelwrightE I Solomon
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D M DooleyH B Gray
Feb 15, 1978·Biochimica Et Biophysica Acta·N MakinoH S Mason
Sep 29, 1978·Biochemical and Biophysical Research Communications·R S HimmelwrightE I Solomon
Feb 14, 1979·Biochemical and Biophysical Research Communications·R S HimmelwrightE I Solomon
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E I SolomonH B Gray
Nov 15, 1973·European Journal of Biochemistry·Y Engelborghs, R Lontie

❮ Previous
Next ❯

Citations

Oct 31, 2002·Angewandte Chemie·Edward I. SolomonAmy E. Palmer
Nov 15, 1990·Biochimica Et Biophysica Acta·E QuéinnecM Vuillaume
Mar 5, 1993·Biochimica Et Biophysica Acta·C R AndrewA G Sykes
Feb 22, 1995·Biochimica Et Biophysica Acta·A Sánchez-FerrerF García-Carmona
Sep 13, 1996·Biochimica Et Biophysica Acta·M Jiménez, F García-Carmona
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J H MartinezJ A Lozano
Jul 14, 2001·Biochimica Et Biophysica Acta·C GerdemannB Krebs
Feb 1, 1982·Quarterly Reviews of Biophysics·K E van Holde, K I Miller
May 1, 2012·Journal of the American Chemical Society·Megen A CulpepperAmy C Rosenzweig
Apr 17, 2009·Journal of the American Chemical Society·Bryan T Op't HoltEdward I Solomon
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Y T Hwang, E I Solomon
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M D AllendorfE I Solomon
Jul 10, 2007·Bioscience, Biotechnology, and Biochemistry·Yasuko Kawamura-KonishiHaruo Suzuki
Mar 5, 2014·Chemical Reviews·Edward I SolomonLi Tian
Aug 28, 1979·Biochemical and Biophysical Research Communications·A F HeppE I Solomon
Apr 1, 1988·Archives of Biochemistry and Biophysics·M BeltraminiB Salvato
Dec 19, 2003·Biochemical and Biophysical Research Communications·Sang Mok Kim, Sanghwa Han
Mar 13, 2014·Phytochemistry·Florime ZekiriAnnette Rompel
Sep 1, 1987·Archives of Biochemistry and Biophysics·P F Fitzpatrick, J J Villafranca
Aug 3, 1981·FEBS Letters·R Torensma, J C Phillips
May 23, 2020·Critical Reviews in Biochemistry and Molecular Biology·Mark-Anthony McLarin, Ivanhoe K H Leung
May 1, 1982·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H J SchneiderA Henschen
May 11, 2019·Science·Matthew O RossBrian M Hoffman
Dec 7, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·David A QuistKenneth D Karlin
Nov 7, 1996·Chemical Reviews·Richard H. HolmEdward I. Solomon
Nov 7, 1996·Chemical Reviews·Edward I. SolomonTimothy E. Machonkin
Jul 11, 1980·Science·J A Ibers, R H Holm
Nov 30, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Grace N OnwubikoBlessing E Onah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.