Mar 31, 2020

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

BioRxiv : the Preprint Server for Biology
Austin G MeyerKrzysztof Pyrc

Abstract

The beginning of 2020 brought us information about the novel coronavirus emerging in China. Rapid research resulted in the characterization of the pathogen, which appeared to be a member of the SARS-like cluster, commonly seen in bats. Despite the global and local efforts, the virus escaped the healthcare measures and rapidly spread in China and later globally, officially causing a pandemic and global crisis in March 2020. At present, different scenarios are being written to contain the virus, but the development of novel anticoronavirals for all highly pathogenic coronaviruses remains the major challenge. Here, we describe the antiviral activity of previously developed by us HTCC compound (N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride), which may be used as potential inhibitor of currently circulating highly pathogenic coronaviruses - SARS-CoV-2 and MERS-CoV.

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Mentioned in this Paper

Immune Response
Virus
Genome
Three-dimensional
Vaccines
Influenza virus vaccine
Influenza
Protein Function
Supernumerary Maxillary Right Lateral Primary Incisor
Persons

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