Geometric control of cell life and death

Science
C S ChenD E Ingber

Abstract

Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment.

References

Jun 1, 1978·Nature·J Folkman, A Moscona
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A SchwartzD E Ingber
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D E Ingber
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·M StokerV Waxman
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·R W TuckerJ Folkman
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D E IngberJ D Jamieson
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z ZhangE Ruoslahti
Oct 1, 1995·The Journal of Clinical Investigation·P C BrooksD A Cheresh
Apr 14, 1995·Science·E A Clark, J S Brugge
Apr 29, 1994·Science·R SinghviD E Ingber
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
Oct 1, 1995·Current Opinion in Cell Biology·C D RoskelleyM J Bissell
Jan 1, 1995·Annual Review of Cell and Developmental Biology·M A SchwartzM H Ginsberg
Jul 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·N Wang, D E Ingber
Aug 1, 1996·The Journal of Cell Biology·S M FrischP Y Chan-Hui
Feb 1, 1996·Current Opinion in Cell Biology·S W Craig, R P Johnson
Jul 21, 1996·Journal of Theoretical Biology·D StamenovićD E Ingber
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J ManiotisD E Ingber
Jan 1, 1997·Annual Review of Physiology·D E Ingber

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Citations

Sep 17, 1998·Lasers in Surgery and Medicine·J T Beranek
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F S Jones, P L Jones
Jul 9, 1999·Journal of Biomedical Materials Research·H NygrenI Lundström
Sep 25, 1999·Journal of Biomedical Materials Research·J S BurmeisterG A Truskey
Jan 25, 2000·Journal of Biomedical Materials Research·Y DoriM Tirrell
Mar 19, 1999·Journal of Cellular Physiology·Y Watanabe, T Akaike
Aug 22, 2000·Journal of Biomedical Materials Research·A FolchM Toner
Feb 24, 2001·Journal of Biomedical Materials Research·S KatoT Matsuda
Feb 24, 2001·Journal of Biomedical Materials Research·T G van KootenC J Kirkpatrick
Jun 28, 2001·Journal of Biomedical Materials Research·K WebbP A Tresco
Apr 5, 2001·Journal of Biomedical Materials Research·L Kam, S G Boxer
Jun 21, 2001·Journal of Biomedical Materials Research·A GoesslA S Hoffman
Feb 12, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L S Price
May 10, 2002·Biotechnology and Bioengineering·Erik F PetersenEric W McFarland
Jul 12, 2002·Cell Motility and the Cytoskeleton·Ning WangDonald E Ingber
Feb 9, 2002·Journal of Biomedical Materials Research·Valerie A LiuSangeeta N Bhatia
Mar 29, 2002·Journal of Biomedical Materials Research·T O Collier, J M Anderson
Jul 13, 2002·Journal of Biomedical Materials Research·P J ter BruggeJ A Jansen
Jul 13, 2002·Journal of Biomedical Materials Research·Tarek Y El SayeghChristopher A G McCulloch
Jul 13, 2002·Journal of Biomedical Materials Research·Dominique P PiolettiJacques Corbeil
Mar 29, 2002·Journal of Biomedical Materials Research·Todd C McDevittPatrick S Stayton
Dec 12, 2001·Biochemical and Biophysical Research Communications·R AikawaI Komuro
Jul 13, 2001·Cell Biology International·R G WilsonA M Zimmerman
May 7, 2002·Cell Biology International·Wolfgang H Goldmann
Aug 21, 2010·Cellular and Molecular Life Sciences : CMLS·Linxia ZhangChristina Chan
Feb 8, 2005·Analytical and Bioanalytical Chemistry·Arjan P QuistSven Oscarsson
Jul 27, 2007·Analytical and Bioanalytical Chemistry·Makiko GotoTakehiko Kitamori
May 19, 2009·Analytical and Bioanalytical Chemistry·Jean-Philippe FrimatJonathan West
Jun 26, 2009·Analytical and Bioanalytical Chemistry·Sen HouChen Wang
Feb 16, 2013·Analytical and Bioanalytical Chemistry·Frank MeinersGunther Wittstock
Jun 21, 2011·European Biophysics Journal : EBJ·Franziska WetzelJosef Käs
Oct 13, 2011·European Biophysics Journal : EBJ·Ye ZengXiao-Heng Liu
Mar 20, 2010·Histochemistry and Cell Biology·Helene M LangevinDouglas J Taatjes
May 31, 2012·Histochemistry and Cell Biology·Federico GalvagniMaurizio Orlandini
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Thomas LudwigUlrich S Schwarz
Apr 19, 2011·Pflügers Archiv : European journal of physiology·Megan L McCain, Kevin Kit Parker
Dec 7, 2013·Molecules and Cells·Morgan Hamon, Jong Wook Hong
Jul 10, 2007·Biomechanics and Modeling in Mechanobiology·G P RaeberJ A Hubbell
Jan 12, 2012·Biomechanics and Modeling in Mechanobiology·Naama Shoham, Amit Gefen
Jul 10, 2012·Biomechanics and Modeling in Mechanobiology·Sean P SheehyKevin Kit Parker
Aug 3, 2012·Biomechanics and Modeling in Mechanobiology·Sagar D Joshi, Lance A Davidson
May 5, 2005·Annals of Biomedical Engineering·James H C WangZhaozhu Li
Dec 13, 2005·Annals of Biomedical Engineering·John A Pedersen, Melody A Swartz

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