Geometric regularization for 2-D myocardial strain quantification in mice: an in-silico study

Ultrasound in Medicine & Biology
Florence KremerJan D'hooge

Abstract

Myocardial strain quantification in the mouse based on 2-D speckle tracking using real-time ultrasound datasets is feasible but remains challenging. The major difficulty lies in the fact that the frame rate-to-heart rate ratio is relatively low, causing significant decorrelation between subsequent frames. In this setting, regularization is therefore particularly important to discard motion estimates that are improbable. Different regularization methods have been proposed, among which is a class of regularizers based on enforcing preset geometrical characteristics of the motion field. To date, these regularization methods have not been contrasted. The aim of this study was thus to compare the performance of different geometric regularizers in the setting of myocardial motion and strain estimation in murine echocardiography using simulated datasets. In normal models, restricting the spatial curvature of the motion fields resulted in worse radial strain estimates (mean root-mean-square [RMS] error increased from 0.06 to 0.09; p < 0.05), but better circumferential strain estimates (mean RMS error decreased from 0.035 to 0.01; p < 0.05). More accurate circumferential strain estimates were also obtained by convolving a Gaussian funct...Continue Reading

References

Feb 1, 1991·Circulation Research·F J VillarrealJ W Covell
Mar 1, 1991·IEEE Transactions on Bio-medical Engineering·L N Bohs, G E Trahey
Jul 1, 1997·Ultrasonic Imaging·F Kallel, J Ophir
Mar 20, 1998·Circulation Research·J F JamesJ Robbins
Mar 12, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Jan D'hoogePaul Suetens
Feb 5, 2003·IEEE Transactions on Medical Imaging·Jan D'hoogePaul Suetens
Jun 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·George R SutherlandBart Bijnens
Dec 17, 2004·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Stian LangelandBart Bijnens
Aug 1, 2006·Ultrasound in Medicine & Biology·Dan RappaportShimon Riesner
Oct 19, 2006·Ultrasound in Medicine & Biology·Stian LangelandJan D'hooge
Jun 9, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Reidar WinterLars-Ake Brodin
Oct 28, 2008·Ultrasound in Medicine & Biology·Wei-Ning LeeElisa E Konofagou
Jun 30, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yu PengMarc S Penn
Aug 4, 2009·Ultrasound in Medicine & Biology·F Stuart FosterAndrew Needles

❮ Previous
Next ❯

Citations

Oct 13, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Matilda LarssonJan D'hooge
Jan 15, 2015·Physics in Medicine and Biology·Matilda LarssonJan D'hooge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.