Geometric surrogates of abdominal aortic aneurysm wall mechanics

Medical Engineering & Physics
Jesús UrrutiaEnder A Finol

Abstract

The maximum diameter criterion is the most important factor in the clinical management of abdominal aortic aneurysms (AAA). Consequently, interventional repair is recommended when an aneurysm reaches a critical diameter, typically 5.0 cm in the United States. Nevertheless, biomechanical measures of the aneurysmal abdominal aorta have long been implicated in AAA risk of rupture. The purpose of this study is to assess whether other geometric characteristics, in addition to maximum diameter, may be highly correlated with the AAA peak wall stress (PWS). Using in-house segmentation and meshing algorithms, 30 patient-specific AAA models were generated for finite element analysis using an isotropic constitutive material for the AAA wall. PWS, evaluated as the spatial maximum of the first principal stress, was calculated at a systolic pressure of 120 mmHg. The models were also used to calculate 47 geometric indices characteristic of the aneurysm geometry. Statistical analyses were conducted using a feature reduction algorithm in which the 47 indices were reduced to 11 based on their statistical significance in differentiating the models in the population (p < 0.05). A subsequent discriminant analysis was performed and 7 of these indice...Continue Reading

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Citations

Jul 28, 2020·Bioengineering·Stephen J HallerSandra Rugonyi
Nov 7, 2020·Annals of Vascular Surgery·Huaxin WangJohn Freebody
Jul 29, 2021·Journal of Biomechanical Engineering·Balaji RengarajanEnder A Finol

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