PMID: 11606260Oct 19, 2001Paper

Geometrical properties of gel and fluid clusters in DMPC/DSPC bilayers: Monte Carlo simulation approach using a two-state model

Biophysical Journal
I P SugárP L Chong

Abstract

In this paper the geometrical properties of gel and fluid clusters of equimolar dimyristoylphosphatidylcholine/distearoylphosphatidylcholine (DMPC/DSPC) lipid bilayers are calculated by using an Ising-type model (Sugar, I. P., T. E. Thompson, and R. L. Biltonen. 1999. Biophys. J. 76:2099-2110). The model is able to predict the following properties in agreement with the respective experimental data: the excess heat capacity curves, fluorescence recovery after photobleaching (FRAP) threshold temperatures at different mixing ratios, the most frequent center-to-center distance between DSPC clusters, and the fractal dimension of gel clusters. In agreement with the neutron diffraction and fluorescence microscopy data, the simulations show that below the percolation threshold temperature of gel clusters many nanometer-size gel clusters co-exist with one large gel cluster of size comparable with the membrane surface area. With increasing temperature the calculated effective fractal dimension and capacity dimension of gel and fluid clusters decrease and increase, respectively, within the (0, 2) interval. In the region of the gel-to-fluid transition the following geometrical properties are independent from the temperature and the state o...Continue Reading

References

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Citations

Sep 30, 2008·Biochimica Et Biophysica Acta·Emel I GoksuMarjorie L Longo
Sep 27, 2002·Biophysical Journal·Ekaterina I Michonova-Alexova, István P Sugár
Sep 28, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Pinaki SenguptaAlex Slepoy
Nov 27, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Patrick S Coppock, James T Kindt
Apr 26, 2020·Biophysical Journal·Anjali GuptaThorsten Wohland
Jan 4, 2019·The Journal of Physical Chemistry. B·Jonathan D NickelsMaikel C Rheinstädter

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