Geometry and force behind kinetochore orientation: lessons from meiosis.

Nature Reviews. Molecular Cell Biology
Yoshinori Watanabe

Abstract

During mitosis, replicated chromosomes (sister chromatids) become attached at the kinetochore by spindle microtubules emanating from opposite poles and segregate equationally. In the first division of meiosis, however, sister chromatids become attached from the same pole and co-segregate, whereas homologous chromosomes connected by chiasmata segregate to opposite poles. Disorder in this specialized chromosome attachment in meiosis is the leading cause of miscarriage in humans. Recent studies have elucidated the molecular mechanisms determining chromosome orientation, and consequently segregation, in meiosis. Comparative studies of meiosis and mitosis have led to the general principle that kinetochore geometry and tension exerted by microtubules synergistically generate chromosome orientation.

References

Mar 15, 1978·Experimental Cell Research·M P Maguire
Apr 6, 1968·Nature·S A Henderson, R G Edwards
Jan 1, 1994·Annual Review of Genetics·W Y Miyazaki, T L Orr-Weaver
Feb 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K W Wolf
Jan 1, 1994·Cytogenetics and Cell Genetics·R R AngellD T Baird
Jan 31, 1997·Science·R B Nicklas
Nov 14, 1997·Current Topics in Developmental Biology·D P Moore, T L Orr-Weaver
Oct 6, 2000·The Journal of Cell Biology·H G Yu, R K Dawe
Apr 3, 2001·Nature Reviews. Genetics·T Hassold, P Hunt
Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Yamamoto, Y Hiraoka
Aug 3, 2001·Nature Reviews. Molecular Cell Biology·H Scherthan
May 16, 2003·Molecular and Cellular Biology·Shihori YokobayashiYoshinori Watanabe
May 17, 2003·Science·Tomoya S KitajimaYoshinori Watanabe
Oct 9, 2003·The EMBO Journal·Tomoya S KitajimaYoshinori Watanabe
Jan 31, 2004·Science·Adele L MarstonAngelika Amon
Aug 4, 2004·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Alison L Pidoux, Robin C Allshire
Oct 28, 2004·Cell·Silke Hauf, Yoshinori Watanabe
Dec 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhanyun TangHongtao Yu
Dec 29, 2004·Current Biology : CB·Brian H LeeAngelika Amon
Jun 3, 2005·Nature Reviews. Genetics·Jennifer L Gerton, R Scott Hawley
Jun 7, 2005·Developmental Cell·Huiling XuMichael J McKay
Jun 11, 2005·Trends in Genetics : TIG·Yoshinori Watanabe
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chad Ellermeier, Gerald R Smith
Aug 9, 2005·Trends in Cell Biology·Benjamin A Pinsky, Sue Biggins
Sep 24, 2005·Journal of Cell Science·Liudmila ChelyshevaMathilde Grelon

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Citations

Feb 23, 2013·Nature Reviews. Molecular Cell Biology·Rong Li, David F Albertini
Nov 5, 2013·Nature Structural & Molecular Biology·Yuki OgiyamaKojiro Ishii
Oct 3, 2013·PLoS Genetics·Jonathan M G Higgins, Mary Herbert
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yingdee Unhavaithaya, Terry L Orr-Weaver
Aug 7, 2013·Current Opinion in Cell Biology·Matthew P MillerElçin Ünal
Feb 18, 2015·The Journal of Cell Biology·Alex FennellJulia Promisel Cooper
Mar 20, 2013·The Journal of Cell Biology·Andrew D StephensKerry Bloom
Jan 21, 2016·The New England Journal of Medicine·Ruizhi FengLei Wang
Sep 12, 2015·Science·Yuji TannoYoshinori Watanabe
Feb 13, 2013·American Journal of Medical Genetics. Part a·NaTasha D HollisLora J H Bean
Jun 12, 2013·The Plant Journal : for Cell and Molecular Biology·Pablo Bolaños-VillegasGuang-Yuh Jauh
Nov 16, 2013·EMBO Reports·Tomoyuki U TanakaToyoaki Natsume
Mar 31, 2015·The FEBS Journal·Emily L Kurdzo, Dean S Dawson
Jul 15, 2015·Molecular Biology of the Cell·Régis E MeyerDean S Dawson
Sep 1, 2015·Frontiers in Oncology·Kuo-Tai YangTang K Tang
Aug 13, 2015·BMC Biology·Yasushi SakaHiroyuki Ohkura
Aug 11, 2015·Chromosoma·Sandra A Touati, Katja Wassmann
Jun 2, 2015·Developmental Cell·Shuhei YoshidaTomoya S Kitajima
Dec 11, 2014·Annual Review of Plant Biology·Raphaël MercierMathilde Grelon
Jul 6, 2014·Frontiers in Plant Science·Linda ZamariolaDanny Geelen
Aug 26, 2016·Cell Cycle·Midori Shimada, Makoto Nakanishi
Nov 7, 2016·Current Opinion in Plant Biology·Shinichiro Komaki, Arp Schnittger
May 5, 2017·Cell Cycle·Shunxin WangLiangran Zhang
May 13, 2017·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Seira MiyazakiYoshinori Watanabe
Jul 12, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Lina WangWei Li
Jul 25, 2017·International Journal of Molecular Sciences·Jin-Mei Cheng, Yi-Xun Liu
Jan 11, 2018·Development, Growth & Differentiation·Tomoya S Kitajima
Jul 10, 2014·Nature Communications·Anna KouznetsovaChrister Höög
Oct 31, 2017·Nature Structural & Molecular Biology·Devon F PendleburyJayakrishnan Nandakumar

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