Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation

Brain Research Bulletin
Tadashi WadaYusuke Morita

Abstract

The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both rapid-eye movement (REM) and non-REM (NREM) sleep were increased in both GGA- and vehicle-injected rats. However, in GGA-injected rats, REM-sleep rebound was significantly suppressed, while NREM-sleep rebound remained unaffected. In addition, the increase of Tcore caused by SD was also attenuated in GGA-injected rats. In the hippocampus, both SD and the GGA pretreatment induced an increase in the expression of HSP70 mRNA, indicating that the SD functions as a stress for hippocampal neurons and that the GGA induces HSP70 expression. The findings suggest that pretreatment with GGA suppresses REM sleep rebound and the response of Tcore against SD.

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Citations

Oct 10, 2014·Journal of Nutritional Science and Vitaminology·Tomohiro ItoJun Nishihira
Mar 9, 2018·Phytotherapy Research : PTR·Ye TianXiukun Lin
Nov 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xianguo ZhaoJuan Du

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