Geriatric Pharmacology

Anesthesiology Clinics
Shamsuddin Akhtar, Ramachandran Ramani

Abstract

Aging involves changes in several physiologic processes that lead to decreased volumes of distribution, slowed metabolism, and increased end-organ sensitivity to anesthetics. These changes generally result in increased potency. Elderly patients require less anesthetic medication, but the true extent of reduction is underappreciated and less uniformly practiced. The impact of potential anesthetic drug overdosing on intermediate and long-term outcomes is not fully appreciated. It may be necessary to consider age as a continuous variable for anesthetic drug dosing in older patients rather than treating adult versus elderly patients. Further pharmacologic studies are required in people more than 85 years old.

References

Sep 1, 1992·British Journal of Anaesthesia·S McCluneR S Clarke
Nov 16, 1994·JAMA : the Journal of the American Medical Association·E R MarcantonioT H Lee
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jun 9, 1999·The American Journal of Psychiatry·J K ZubietaJ J Frost
Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Aug 10, 2000·Anesthesiology Clinics of North America·S L Shafer
Oct 21, 2000·European Journal of Clinical Nutrition·B Beaufrère, B Morio
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Jun 12, 2001·Current Opinion in Neurobiology·S Cull-CandyM Farrant
Jan 7, 2003·Drugs & Aging·Mellar P Davis, Manish Srivastava
May 23, 2003·The New England Journal of Medicine·Jason A CampagnaStuart A Forman
Jul 25, 2003·British Journal of Anaesthesia·R W D Nickalls, W W Mapleson
Sep 12, 2003·Journal of Cardiothoracic and Vascular Anesthesia·G Alec Rooke
Dec 17, 2003·Acta Anaesthesiologica Scandinavica·A SchultzB Schultz
Jun 1, 2004·Pharmacological Reviews·Allan J McLean, David G Le Couteur
Dec 24, 2004·Anesthesia and Analgesia·Terri G MonkJeffrey C Sigl
Apr 9, 2005·European Journal of Anaesthesiology·S KreuerW Wilhelm
Aug 24, 2005·Anesthesia and Analgesia·David L ReichCarol A Bodian
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Feb 24, 2006·Journal of Cognitive Neuroscience·Cheryl L GradyGordon Winocur
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Nov 13, 2007·The American Journal of Geriatric Pharmacotherapy·Mark W Bowie, Patricia W Slattum
Jan 16, 2008·Clinical Pharmacokinetics·Martin WhiteStefan Schraag
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
Apr 18, 2009·Anesthesia and Analgesia·Jaap VuykAlbert Dahan
Jun 6, 2009·European Journal of Anaesthesiology·Andrea Kopp LugliChristoph H Kindler
Nov 26, 2010·Clinics in Geriatric Medicine·Qian-Li Xue
Mar 2, 2011·Current Opinion in Nephrology and Hypertension·Norberto PericoAriela Benigni
Sep 20, 2011·Best Practice & Research. Clinical Anaesthesiology·Tomás B Corcoran, Samuel Hillyard
Jan 1, 2011·Brain Connectivity·Marcus E Raichle
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaakko W LångsjöHarry Scheinin
Nov 17, 2012·Brain Connectivity·Anthony G Hudetz
Dec 28, 2012·Critical Care Medicine·Juliana BarrUNKNOWN American College of Critical Care Medicine

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Citations

Dec 1, 2017·Current Opinion in Anaesthesiology·Shamsuddin Akhtar
Mar 7, 2021·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Karen E AlsbrookSusan W Wesmiller

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