PMID: 9535502Apr 16, 1998Paper

Germ cell apoptosis in rat testis after administration of 1,3-dinitrobenzene

Reproductive Toxicology
C Strandgaard, M G Miller

Abstract

The present study investigated the occurrence of apoptosis in rat testis 6, 12, 24, or 48 h after administration of 1,3-dinitrobenzene (DNB)(25 mg/kg, i.p.). Apoptotic cells were visualized using TUNEL in situ detection. In untreated control animals, occasional tubules contained a few apoptotic nuclei. After DNB treatment, more tubules were apoptotic and more germ cells within individual tubules were affected. The increase in incidence and severity of apoptosis was statistically significant 24 and 48 h after exposure. Spermatocytes were the primary cell population affected. Apoptosis was primarily present in Stages VI-VIII and IX-XIII. DNA ladders, characteristic of apoptosis, were clearly present by 24 h after DNB administration, faint at 12 h, and not present in the control or at 6 h. Although initiating mechanisms may be very different for different chemicals, apoptosis is a common and late manifestation of the testicular response to numerous toxicants.

References

Dec 15, 1975·Biochemical and Biophysical Research Communications·R P Mason, J L Holtzman
Feb 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M F ObasajuM G Miller
Jan 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D A Cave, P M Foster
Jan 1, 1988·Toxicology and Applied Pharmacology·D M BlackburnP M Foster
May 1, 1981·Journal of Toxicology and Environmental Health·T E CodyR T Christian
Sep 1, 1995·Journal of Reproduction and Fertility·M H BrinkworthE Nieschlag
Dec 1, 1994·Immunological Reviews·D J McConkeyS Orrenius
Apr 1, 1993·Endocrine Reviews·R A Schwartzman, J A Cidlowski
Jan 8, 1996·FEBS Letters·C RichterC Franceschi
Nov 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S F McEuenM G Miller
Dec 1, 1995·Toxicology Letters·A F SlaterS Orrenius
Feb 23, 1996·Biochemical Pharmacology·E EnanF Matsumura
Apr 1, 1996·The Journal of Experimental Medicine·N ZamzamiG Kroemer
Oct 1, 1996·The Journal of Experimental Medicine·S A SusinG Kroemer
Oct 28, 1996·FEBS Letters·P X PetitG Kroemer
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P M FosterM S Prout

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Citations

Feb 5, 2003·Toxicology Letters·Il-Hwan KimBoo-Hyon Kang
Nov 21, 2000·Free Radical Biology & Medicine·A V Rao, C Shaha
Jun 28, 2011·Asian Journal of Andrology·Premendu Prakash Mathur, Shereen Cynthia D'Cruz
Jan 24, 2016·Reproductive Toxicology·Keith M GoldsteinThomas K Baker
Jul 31, 2012·Toxicology Letters·Sophie LudwigRémi Bars
Oct 11, 2011·Toxicology·Takuya MatsuyamaAtsushi Sanbuissho
Mar 17, 2010·Chemico-biological Interactions·S VaithinathanP P Mathur
Sep 27, 2005·Contraception·Francesca MaranghiLuciano Saso
Feb 24, 2001·Toxicologic Pathology·D M Creasy
Aug 2, 2001·Journal of Applied Toxicology : JAT·N AdhikariD K Saxena

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis