Germ cell cancer and disorders of spermatogenesis: an environmental connection?

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
N E SkakkebaekJ Müller

Abstract

Why is there a small peak of germ cell tumours in the postnatal period and a major peak in young age, starting at puberty? And, paradoxically, small risk in old age, although spermatogenesis is a lifelong process? Why is this type of cancer more common in individuals with maldeveloped gonads, including undescended testis, gonadal dysgenesis and androgen insensitivity syndrome? Why has there, during the past 50 years, been a quite dramatic increase in testicular cancer in many developed countries? These are just a few of many questions concerning testicular cancer. However, the recent progress in research in the early stages of testicular cancer (carcinoma in situ testis (CIS)) allows us to begin to answer some of these questions. There is more and more evidence that the CIS cell is a gonocyte with stem cell potential, which explains why an adult man can develop a non-seminoma, which is a neoplastic caricature of embryonic growth. We consider the possibility that CIS cells may loose their stem cell potential with ageing. Along these lines, a seminoma is regarded a gonocytoma where the single gonocytes have little or no stem cell potential. The Sertoli and Leydig cells, which are activated postnatally and during and after puberty...Continue Reading

References

Aug 11, 1979·British Medical Journal·J G BerthelsenB L Sørensen
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Aug 1, 1991·The Journal of Urology·D S HuffJ W Duckett
Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·H G BurgerG L Warne
Sep 26, 1987·British Medical Journal·R Morley, A Lucas
Feb 1, 1987·International Journal of Andrology·A F HolsteinM Hartmann
Jun 1, 1987·European Journal of Cancer & Clinical Oncology·P BoyleA G Robertson
Dec 1, 1987·The Journal of Urology·R R NewboldJ A McLachlan
Jun 1, 1986·International Journal of Epidemiology·L M BrownJ T Flannery
Jun 1, 1970·Cancer·R E Scully
Jun 1, 1974·Fertility and Sterility·C M Nelson, R G Bunge
Jun 1, 1983·International Journal of Andrology·J G Berthelsen, N E Skakkebaek
Jan 1, 1981·Scandinavian Journal of Urology and Nephrology·J G Berthelsen, N E Skakkebaek
May 25, 1995·The New England Journal of Medicine·A J WilcoxA L Herbst
Feb 2, 1995·The New England Journal of Medicine·J AugerP Jouannet
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K P Dieckmann
Oct 1, 1994·International Journal of Cancer. Journal International Du Cancer·H O AdamiM Rahu
May 1, 1994·Current Opinion in Oncology·R T Oliver
Jan 1, 1993·European Journal of Pediatrics·D S HuffJ W Ducket
Jan 1, 1996·Epidemiology·A PrenerO M Jensen
Feb 1, 1996·The Journal of Pathology·E Rajpert-De MeytsN E Skakkebaek
Jun 1, 1996·Virchows Archiv : an International Journal of Pathology·E Rajpert-De MeytsN E Skakkebaek
Feb 1, 1996·International Journal of Andrology·M VierulaJ Suominen
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Feb 27, 1997·Nature·I WilmutK H Campbell
Jan 1, 1997·Clinical Endocrinology·P M CroftonC J Kelnar
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P M PetersenA Giwercman
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Rajpert-De MeytsN E Skakkebaek
Nov 1, 1953·American Journal of Obstetrics and Gynecology·W J DIECKMANNR E POTTINGER
Mar 1, 1981·International Journal of Andrology·Johannes Clemmesen
Mar 1, 1981·International Journal of Andrology·Niels E Skakkebaek, Jørgen G Berthelsen

❮ Previous
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Citations

Dec 15, 2004·Anatomy and Embryology·Folker E FrankeKlaus Steger
Apr 23, 2005·Cell and Tissue Research·Kristian AlmstrupNiels E Skakkebaek
Oct 25, 2008·Journal of Pediatric Urology·Hideki TomiyamaJohn M Hutson
Dec 26, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Charbel MassaadSamir Hamamah
Jan 16, 1999·Baillière's Clinical Endocrinology and Metabolism·J Toppari, N E Skakkebaek
Sep 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·S HirataK Hoshi
Mar 2, 2005·Nature Reviews. Cancer·J Wolter Oosterhuis, Leendert H J Looijenga
Jul 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Blomberg JensenE Rajpert-De Meyts
Feb 11, 2003·The Journal of Urology·Goro SasakiMasaru Murai
Jun 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H E VirtanenJ Toppari
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Rajpert-De MeytsN E Skakkebaek
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Sep 22, 2000·Archives of Disease in Childhood·C J PartschW G Sippell
Sep 29, 2000·BMJ : British Medical Journal·D de Kretser
May 28, 2005·Endocrinology·Monica Muñoz-de-ToroAna M Soto
Mar 21, 2007·Environmental Health Perspectives·Milena DurandoMónica Muñoz-de-Toro
Apr 24, 2007·Environmental Health Perspectives·Perinaaz R WadiaAna M Soto
Jul 26, 2007·Archives of Environmental & Occupational Health·Fiametta NoriIrene Figà-Talamanca
Jan 24, 2014·International Journal of Molecular Sciences·Nicolas ChevalierPatrick Fénichel
May 6, 2014·Annales d'endocrinologie·Virginie Rouiller-FabreGabriel Livera
Jan 24, 2012·Drug and Chemical Toxicology·Małgorzata M Dobrzyńska, Joanna Radzikowska
Jul 6, 2006·Neoplasia : an International Journal for Oncology Research·Ralph BrehmMartin Bergmann
Dec 11, 2002·Chest Surgery Clinics of North America·Jane Houldsworth
Sep 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Inge A OlesenNiels E Skakkebaek
Sep 11, 2007·Reproductive Toxicology·Laura N VandenbergWade V Welshons
Jan 22, 2008·International Journal of Andrology·Si Brask SonneHenrik Leffers
Sep 24, 2008·International Journal of Experimental Pathology·Yunmin LiYun-Fai Chris Lau
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Gert-Jan M van de GeijnLeendert H J Looijenga
Feb 11, 2009·Cancer·Janet R DalingStephen M Schwartz
Jul 28, 2011·International Journal of Andrology·R Waheeb, M-C Hofmann
Jul 28, 2011·International Journal of Andrology·Ewa Rajpert-De Meyts, Niels E Skakkebaek
Dec 7, 2010·International Journal of Andrology·B TrabertK A McGlynn
Oct 7, 2010·Cancer·Britton TrabertKatherine A McGlynn

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