Germ cell kinetics during early ovarian differentiation: an analysis of the oogonial cell cycle and the subsequent changes in oocyte development during the onset of meiosis in the rat

Microscopy Research and Technique
H WartenbergW Hilscher

Abstract

The aim of this study was the comparison between the mitoses of oogonia and the initial stages of oocyte meiosis. The structural alterations that the germ cell chromatin undergoes during the oogonial mitosis have been compared with those occurring during the G1- and S-phase just before meiosis. Using plastic embedded 1-microm sections of fetal rat ovaries (embryonic days = ED 14-20) labeled with 3H-thymidine and re-embedded for electron microscopy, a study of the structural conditions of the nuclear chromatin has been combined with a kinetic analysis of the oogonial cell cycle and the transitional period into the meiotic prophase. After ovarian differentiation (ED 14) the oogonia show a non-clonal, but strong proliferation. On ED 16, proliferation changes to a clonal pattern and decreases during ED 17. A final increase in 3H-thymidine incorporation on ED 18 characterizes the meiotic S-phase. On ED 19 the nuclear labeling drops to zero. The mitotic cycle of the oogonia lasts 16.5 hr and can be divided into 11 stages according to the concept of El-Alfy and Leblond [(1988) Am. J. Anat., 183:45-56] on the basis of the chromatin pattern. The S-phase (10.0 hours) extends from the telophase-interphase transition through the interphase...Continue Reading

References

Jan 1, 1977·Cytogenetics and Cell Genetics·M Hartung, A Stahl
Feb 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D F Albertini
Sep 1, 1965·Experimental Cell Research·M CroneH Peters
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Citations

Jul 26, 2007·BMC Developmental Biology·Fataneh GhafariGeraldine M Hartshorne
Feb 17, 2009·Molecular Human Reproduction·Ayhan KocerIan R Adams
Aug 28, 2009·Molecular Human Reproduction·Candace TingenTeresa K Woodruff
Apr 4, 1998·Microscopy Research and Technique·M El-Alfy
Dec 17, 2009·Reproduction, Fertility, and Development·Mario Binelli, Bruce D Murphy
Nov 22, 2019·Molecular Reproduction and Development·Luis Francisco RossiMaurizio Zuccotti
Jan 9, 2007·Human Reproduction·Morten F GjerstorffHenrik J Ditzel

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