PMID: 11606249Oct 19, 2001Paper

Germ cell nuclear factor

The International Journal of Biochemistry & Cell Biology
A C Chung, A J Cooney

Abstract

Germ cell nuclear factor (GCNF) is an orphan nuclear receptor for which a ligand has yet to be identified. However, we do know that GCNF binds to a novel response element as a homodimer and regulates expression of genes, such as the protamines, through this element. In the absence of a ligand, GCNF is a transcriptional repressor that interacts with co-repressors. During embryonic development, GCNF is expressed between the gastrula and neurula stages. Loss of GCNF causes embryonic lethality, disrupts normal somitogenesis, as well as neural tube and axis formation, suggesting that GCNF is a critical factor for normal embryonic development. In adult vertebrates, GCNF expression is predominantly found in the germ cells of gonads. GCNF expression in germ cells suggests that understanding its function in adults will yield greater insight into the regulation of gametogenesis, leading to new contraceptive targets.

References

Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Nov 1, 1996·Mechanisms of Development·T O JoosC Dreyer
May 2, 1997·Biochimica Et Biophysica Acta·M KapelleW D Schleuning
Jul 21, 1998·Molecular Reproduction and Development·G C HummelkeA J Cooney
Apr 29, 1999·Cell·UNKNOWN Nuclear Receptors Nomenclature Committee

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Citations

Aug 21, 2014·PloS One·Davood SabourAustin J Cooney
Dec 4, 2003·Molecular Reproduction and Development·Alexandra Zilz, Geoffrey M Cooper
Oct 24, 2017·Journal of Cellular Biochemistry·Sung-Won ParkJae-Hwan Kim
May 6, 2017·Clinical Science·Jimmy El HokayemZafar Nawaz

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