Germ Cell Tumors with Malignant Somatic Transformation: A Mayo Clinic Experience

Oncology Research and Treatment
Caleb J ScheckelTalal Hilal

Abstract

Germ cell tumors (GCTs) with malignant somatic transformation (MST) represent an uncommon variant of what is typically a curable malignancy. There is a paucity of data on time of somatic transformation, response to conventional therapy, and survival outcomes of different somatic subtypes. After obtaining institutional review board (IRB) approval, we searched our institutional database from 1982 to 2017 and identified patients with GCTs with MST. Patient characteristics, pathologic description, treatment, and clinical outcomes were extracted from the medical records. We identified 24 cases of GCTs with MST; the MST was adenocarcinoma in 50% and sarcoma in 50%. Median age at diagnosis was 27. Alpha-fetoprotein and beta-human chorionic gonadotropin were undetectable in 44%, both were elevated in 54%. The majority were advanced stage (71% stage III), and International Germ Cell Cancer Collaborative Group (IGCCCG) risk was classified as 'good' in 60%. Median follow-up was 41 months (range 10-346 months). Median progression-free survival was 84 months (95% confidence interval (CI) 56-232), and median overall survival was 219 months (95% CI 165-not reported). Patients with GCTs with an MST appear to have poor responses to cisplatin-ba...Continue Reading

References

Jul 1, 1979·Cancer·S H PreissigH W Huntington
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessia C DonadioGeorge J Bosl
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Mark P PurdueKatherine A McGlynn
Sep 27, 2005·Annals of Surgical Oncology·Brett S Carver, Joel Sheinfeld
Aug 28, 2007·The American Journal of Surgical Pathology·Hugo Domínguez MalagónSaul Suster
Nov 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brett S CarverJoel Sheinfeld
Jun 30, 2009·The American Journal of Surgical Pathology·Charles C GuoBogdan Czerniak
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jun 26, 2018·Current Opinion in Urology·Ryan SpeirTimothy A Masterson
Oct 7, 2018·Nature Reviews. Disease Primers·Liang ChengLeendert H J Looijenga

❮ Previous
Next ❯

Citations

Sep 4, 2019·The American Journal of Surgical Pathology·Muhammad T IdreesJonathan I Epstein
Dec 23, 2020·The Journal of Thoracic and Cardiovascular Surgery·Yogesh Patel, Chadrick E Denlinger
Mar 6, 2021·International Journal of Surgery Case Reports·Maciej RachwalikRoman Przybylski
Aug 10, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·Rodrigo Cárdenas-Perilla
Oct 3, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Iván A GonzálezLouis P Dehner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.