Germ cells enter meiosis in a rostro-caudal wave during development of the mouse ovary

Molecular Reproduction and Development
Monica Bullejos, P Koopman

Abstract

Germ cells in the mouse embryo remain undifferentiated until about 13.5 days post-coitum (dpc), when male germ cells enter mitotic arrest and female germ cells enter meiosis. The molecular signals and transcriptional control mechanisms governing the differential fate of germ cells in males and females remain largely unknown. In order to gain insights into the behavior of germ cells around this period and into likely mechanisms controlling entry into meiosis, we have studied by wholemount in situ hybridization the expression pattern of two germ cell-specific markers, Oct4 and Sycp3, during mouse fetal gonad development. We observed a dynamic wave of expression of both genes in developing ovaries, with Oct4 expression being extinguished in a rostro-caudal wave and Sycp3 being upregulated in a corresponding wave, during the period 13.5-15.5 dpc. These results indicate that entry into meiosis proceeds in a rostro-caudal progression, in turn suggesting that somatically derived signals may contribute to the control of germ cell entry into meiosis in developing ovaries.

References

Nov 1, 1975·Journal of Reproduction and Fertility·A G Byskov
Mar 29, 1990·Nature·H R SchölerP Gruss
Nov 1, 1991·Human Genetics·P E Polani, J A Crolla
May 9, 1991·Nature·P KoopmanR Lovell-Badge
Jan 1, 1986·Annual Review of Genetics·E M Eicher, L L Washburn
Jan 1, 1987·Differentiation; Research in Biological Diversity·C M NagamineG C Koo
Jan 1, 1985·The Journal of Experimental Zoology·S Francavilla, L Zamboni
Apr 6, 1968·Nature·S A Henderson, R G Edwards
Aug 6, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R G Edwards
Aug 6, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Peters
Nov 1, 1983·The Journal of Experimental Zoology·L Zamboni, S Upadhyay
Mar 1, 1981·Journal of Reproduction and Fertility·A McLaren
Feb 14, 1980·Nature·A McLaren
Jan 1, 1993·Methods in Enzymology·D G Wilkinson, M A Nieto
Jan 1, 1993·Molecular Reproduction and Development·A G ByskovC Y Andersen
Nov 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A McLaren
Jul 1, 1997·Developmental Biology·A McLaren, D Southee
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A BrehmH R Schöler
May 16, 1998·Developmental Biology·C M NagamineD Chang
Jul 14, 1998·Nature Genetics·A K HadjantonakisA Nagy
Nov 14, 1998·Seminars in Cell & Developmental Biology·M Bendel-StenzelC Wylie
Dec 10, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A G ByskovC Y Andersen
Feb 13, 1999·Cell·C Wylie
Aug 30, 2000·Molecular and Cellular Endocrinology·A McLaren
Feb 15, 2001·Cytogenetics and Cell Genetics·U Drews
May 29, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Bullejos, P Koopman
Jan 11, 2002·Developmental Biology·K A MolyneauxC Wylie
Sep 1, 1976·Developmental Biology·A G Byskov, L Saxén
Mar 6, 2003·Gene Expression Patterns : GEP·Douglas B Menke, David C Page
Jun 12, 2003·Developmental Biology·Kelly A McClellanTeruko Taketo
Mar 1, 1957·The Journal of Experimental Zoology·B MINTZ, E S RUSSELL
Oct 11, 2003·Developmental Biology·Douglas B MenkeDavid C Page

❮ Previous
Next ❯

Citations

Aug 10, 2011·Transgenic Research·Jeffrey R SommerRobert M Petters
Dec 25, 2012·Nature Cell Biology·Diana J Laird
Jul 31, 2010·Human Reproduction·R Le BouffantG Livera
Oct 30, 2012·Human Reproduction Update·S M NelsonR A Anderson
Aug 5, 2008·Molecular Human Reproduction·Andrew J ChildsRichard A Anderson
Aug 28, 2009·Molecular Human Reproduction·Candace TingenTeresa K Woodruff
May 23, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·E K Ungewitter, H H-C Yao
Sep 6, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·J Bowles, P Koopman
Sep 19, 2008·BMC Developmental Biology·Craig A SmithAndrew H Sinclair
Mar 3, 2012·PLoS Genetics·Yitzhak ReizelEhud Shapiro
Nov 19, 2013·PLoS Genetics·Brian DeVealeDerek van der Kooy
Jun 16, 2011·PloS One·Andrew J ChildsPhilippa T K Saunders
Jul 31, 2012·PloS One·Huijun ChenDagmar Wilhelm
Sep 17, 2013·PloS One·Adriana Rodríguez-MaríJohn H Postlethwait
Aug 8, 2014·PLoS Genetics·Jana KoubovaDavid C Page
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Josephine Bowles, Peter Koopman
Aug 10, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Jeffrey B KerrRichard A Anderson
Dec 3, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Tamara J StraussStephen R Hammes
Nov 23, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Mai A Sarraj, Ann E Drummond
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jana KoubovaDavid C Page
Dec 29, 2009·Molecular and Cellular Endocrinology·Katherine A Ewen, Peter Koopman
Apr 25, 2007·Gene Expression Patterns : GEP·Melissa H LittleJing Yu
Mar 30, 2010·Reproduction in Domestic Animals = Zuchthygiene·P ZhangW J Xing
Mar 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hyunjoo J LeeKenneth H Albrecht
Mar 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Terje SvingenPeter Koopman
Sep 23, 2006·Stem Cells·Joanna Maldonado-SaldiviaPatrick S Western
Aug 14, 2012·Journal of Cellular Physiology·Xinyi MuGuoliang Xia
Jan 29, 2014·Reproduction in Domestic Animals = Zuchthygiene·V Kasimanickam, R Kasimanickam
Jan 25, 2005·Molecular and Cellular Endocrinology·Humphrey Hung-Chang Yao
Oct 20, 2011·Developmental Biology·Verónica Díaz-HernándezHoracio Merchant-Larios
Apr 5, 2015·Current Opinion in Genetics & Development·Yi-Tzu Lin, Blanche Capel
May 31, 2011·Developmental Biology·Anthony D KrentzDavid Zarkower
Oct 1, 2013·Molecular and Cellular Endocrinology·Chun-Wei FengPeter Koopman
Jul 11, 2006·Current Biology : CB·Amanda Swain
Dec 25, 2007·Developmental Biology·Stefan Bagheri-FamVincent R Harley
Aug 26, 2006·Developmental Biology·Sarah K Bristol-GouldTeresa K Woodruff
Apr 13, 2007·Developmental Biology·Yifei LiuLin Liu
Aug 27, 2014·Developmental Biology·Raphael H RastetterDagmar Wilhelm
Feb 27, 2016·Molecular Human Reproduction·Kun GuoPing Zheng
Sep 18, 2015·PLoS Genetics·Y Q Shirleen SohDavid C Page

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.