Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P ChaubertP Shaw

Abstract

The molecular mechanisms of hepatocarcinogenesis are poorly understood. Only very recently has there been a suggestion of familial hepatocellular carcinoma (HCC). We have analyzed the status of the p16INK4(MTS1) gene, a cyclin-dependent kinase inhibitor, in 26 patients with HCC of different etiologies. Four patients carried hemizygous germ-line point mutations of the p16INK4(MTS1) gene, suggesting the existence of familial HCC involving this gene. The wild-type allele was lost in the tumor in 2 of these 4 patients. Three of the patients carrying a germ-line mutation had non-cirrhosis-associated HCC. No somatic mutations of p16INK4(MTS1) were observed in the 26 cases of HCC. The most common somatic alteration of the p16INK4(MTS1) gene in HCC was de novo methylation, which was detected in 48% of the cases. Low levels (21%) of p16INK4(MTS1) gene allele loss were observed. Altogether, these results indicate that alteration of the p16INK4(MTS1) gene plays an important role in the genesis of HCC.

Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ItoM Monden
May 4, 2013·Medical Molecular Morphology·Yasunobu MatsudaTakafumi Ichida
Mar 8, 2000·Cancer Genetics and Cytogenetics·J LaesJ Szpirer
Aug 10, 2001·Journal of Hepatology·A TannapfelC Wittekind
Jul 16, 2002·Gut·A TannapfelC Wittekind
Oct 11, 2002·The Journal of Pathology·Anette WeberAndrea Tannapfel
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Karel CacaFrieder Berr
Oct 16, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Franco TrevisaniMauro Bernardi
Jan 20, 2009·Science in China. Series C, Life Sciences·Jian Huang
Mar 18, 2003·International Journal of Cancer. Journal International Du Cancer·Marine Gross-GoupilAntoinette Lemoine
Dec 24, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Yongfeng WangFengmin Lu
Apr 19, 2011·International Journal of Cancer. Journal International Du Cancer·Ole AmmerpohlJochen Hampe
Oct 7, 2006·The Journal of Surgical Research·Iain H McKillopLeonidas G Koniaris
Aug 20, 2003·Pathology, Research and Practice·Anette WeberAndrea Tannapfel
Aug 1, 2015·Melanoma Research·Sebastian Burgstaller-MuehlbacherIchiro Okamoto
Aug 11, 2000·Seminars in Cancer Biology·M A Buendia
Mar 16, 2002·Revista Do Instituto De Medicina Tropical De São Paulo·Marcelo Eidi NitaJoaquim J Gama-Rodrigues
Apr 24, 2002·Oncogene·Mark A FeitelsonZhaorui Lian
Nov 13, 2001·Oncogene·A TannapfelC Wittekind
Mar 1, 2013·Hepatology International·Iván Lyra-GonzálezJuan Armendáriz-Borunda
Dec 29, 2000·Seminars in Surgical Oncology·M E Reeves, R P DeMatteo
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takashi UekiAsif Rashid
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin LiMasatoshi Makuuchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.