Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility

Carcinogenesis
M EstellerJ Reventos

Abstract

We describe here a case-control study to identify associations between polymorphisms at the methylenetetrahydrofolate reductase (MTHFR) and cytochrome P-450 1A1 (CYP1A1) genes and susceptibility to endometrial cancer. Accordingly, genotype frequencies in 80 endometrial carcinoma patients were compared with frequencies in 60 controls. DNA analysis suggest a significantly increased endometrial cancer risk with an alanine to valine substitution at nucleotide 677 of MTHFR gene with an odds ratio of 2.8 (95% confidence interval: 1.36-6.14, P = 0.002). Moreover, the tumors from patients with the valine allele were more undifferentiated (P = 0.03). On the other hand, a recently described mutation in exon 7 of CYP1A1 gene (threonine exchanged to asparagine in codon 461) showed a strong association with endometrial cancer risk with an odds ratio of 6.36 (95% confidence interval: 1.99-26.5, P = 0.0004). Thus, this study suggests that polymorphisms at MTHFR and a novel CYP1A1 variant could influence susceptibility to endometrial cancer, although larger sample sizes would be required to corroborate these findings.

Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·M KrajinovicD Sinnett
Mar 29, 2002·Cancer·Giovanni AlmadoriBruno Giardina
Jul 13, 2006·Archives of Gynecology and Obstetrics·D HerrD Pietrowski
Oct 26, 2006·Breast Cancer Research and Treatment·Anna JakubowskaUte Hamann
Jan 23, 2010·Digestive Diseases and Sciences·Dayna S EarlyReina Armamento-Villareal
Mar 9, 2013·Familial Cancer·Bente A Talseth-PalmerRodney J Scott
Mar 1, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bassam LajinAmal Alachkar
Mar 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhenzhong ZhangBengt Lindholm
Mar 12, 2004·Mutation Research·Lidia Maria Fonte AmorimLuis Felipe Ribeiro Pinto
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Gershoni-BaruchE Friedman
Feb 27, 2003·Breast Cancer Research and Treatment·Jan C SemenzaHoda Anton-Culver
Oct 24, 2003·Breast Cancer Research and Treatment·Uwe LangsenlehnerHellmut Samonigg
Aug 22, 2002·Nature Reviews. Cancer·Shi Huang
Jul 27, 2000·Food Additives and Contaminants·L S Birnbaum, J Tuomisto
Jan 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Theodoros N SergentanisNikos F Vlahos
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I EsinlerA Ayhan
Mar 4, 2000·Journal of Medical Genetics·R S Houlston, I P Tomlinson
May 7, 1999·Environmental Health Perspectives·A Hirvonen
Mar 25, 2006·Future Oncology·Sokbom KangJae Weon Kim
Apr 8, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Ugur DeligezerNejat Dalay
Aug 15, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·T Friedberg
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·B Schwahn, R Rozen
Sep 11, 2008·Pharmacogenomics·Giuseppe Toffoli, Elena De Mattia
Dec 7, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Shams TabrezSyed Kashif Zaidi
Aug 25, 2007·Cancer Causes & Control : CCC·Monica McGrathImmaculata De Vivo
May 5, 2005·American Journal of Epidemiology·L F MassonJ Little
Mar 26, 2016·Advanced Biomedical Research·Ghorban MohammadzadehSeyed-Mohammad Hosseini
Dec 22, 2015·Journal of Gastrointestinal Cancer·Ruhi DixitVijay Kumar Shukla
Nov 3, 2015·Taiwanese Journal of Obstetrics & Gynecology·Xian-Jun WangJin Mei
Sep 8, 2010·Gynecologic Oncology·Kathryn L TerryDaniel W Cramer
Oct 31, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C MarchalJ Carnero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R Gershoni-BaruchE Friedman
Proceedings of the National Academy of Sciences of the United States of America
C F SkibolaG Morgan
Breast Cancer Research and Treatment
Jan C SemenzaHoda Anton-Culver
© 2021 Meta ULC. All rights reserved