PMID: 9524437Apr 1, 1997Paper

Germ theory vs. community theory in understanding and controlling the proliferation of biofilms

Advances in Dental Research
D E CaldwellG M Wolfaardt

Abstract

Germ theory and pure culture methods have provided invaluable information concerning the role of bacteria in diseases resulting from a single organism which bypasses a host's defenses. However, they do not provide sufficient information concerning the synergisms which allow the members of biofilm communities to proliferate more effectively as communities rather than as individuals. The mechanisms of these synergies are potential targets for antimicrobial agents as well as potential mechanisms of resistance to antimicrobial agents. Understanding community-level phenomena in oral biology requires the culture, identification, and classification of functional plaque communities as well as new methods of identifying and quantifying communal relationships. Cultured biofilm communities also provide ideal models of bacterial self-organization in which information related to adaptive strategies arises not only through the recombination of genes within genomes, but also through the recombination of organisms within communities.

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Citations

Sep 26, 2002·Journal of Clinical Periodontology·S G RüdigerJ Olsson
Feb 17, 2009·Applied and Environmental Microbiology·Sarah M BoomerBryan E Dutton
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M E Davey, G A O'toole
Nov 26, 2009·Canadian Journal of Microbiology·Elanna BesterGideon M Wolfaardt
Jan 11, 2011·Journal of Conservative Dentistry : JCD·L Lakshmi Narayanan, C Vaishnavi
Jul 7, 2010·International Wound Journal·Steven L PercivalDavid W Williams
Mar 15, 2015·Journal of International Society of Preventive & Community Dentistry·Kapil JhajhariaLata Kiran Mehta
May 2, 2016·Journal of Dentistry·Christina P C SimEric C Reynolds
Apr 1, 1997·Advances in Dental Research·C H Sissons
Aug 28, 2004·Periodontology 2000·Tatsuji Nishihara, Takeyoshi Koseki
Dec 25, 2015·Microbiology and Molecular Biology Reviews : MMBR·Hongyue Dang, Charles R Lovell
Sep 27, 2018·Dentistry Journal·James L Gutmann, Vivian Manjarrés

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