[German adrenocortical carcinoma registry. Surgical therapy results and follow-up treatment].

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
J ReibetanzMartin Fassnacht

Abstract

Adrenocortical carcinoma (ACC) is a highly aggressive endocrine disease with an incidence of 1-2 cases per million population per year. Due to the low incidence of ACC knowledge concerning the surgical management is mainly based on retrospective studies or recommendations of isolated experts. Cancer databases, such as the German ACC registry are prerequisite to collect and evaluate clinical data from a large number of patients. For non-metastatic tumor stages, complete tumor resection is the only treatment with curative intent. Open surgery remains the recommended approach for ACC. However, in small tumors with uncertain malignancy a laparoscopic resection by an expert surgeon can be considered. A loco-regional lymphadenectomy should be part of the primary surgical treatment of ACC. Tumor recurrence is common even after an apparently complete primary resection. Therefore, based on the individual risk (tumor size, resection status, proliferation index) adjuvant mitotane treatment is recommended in most patients. Patients with low-risk should be included in the ADIUVO trial. In case of tumor relapse indications for a reoperation should be strongly considered, especially when the time interval since the primary surgery is long (> ...Continue Reading

References

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Citations

May 29, 2014·International Journal of Surgery·Giacomo BenassaiGennaro Quarto
Jun 21, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Martin StrakaMatej Skrovina
Dec 24, 2015·Journal of Endocrinological Investigation·F PorpigliaM Terzolo
Jun 18, 2021·Analytical and Bioanalytical Chemistry·Huiyi YangSuqing Zhao

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