Germanium Reduces Inflammatory Damage in Mammary Glands During Lipopolysaccharide-Induced Mastitis in Mice.

Biological Trace Element Research
Yong-Sheng WangChun-Liu Dong

Abstract

Ge is a trace element needed for good nutrition and health protection in animals and humans. Ge can be consumed by drinking or eating or administered by injection and transferred with the blood to exert pharmacological activities. The blood is important in the formation of milk. Mastitis is a serious health hazard in animals and humans. The present study explored the effect of Ge on mastitis and the potential underlying mechanism. A mastitis mouse model was established with LPS. mMECs were prepared for study in vitro. Histopathological changes showed that Ge had a protective effect on mammary gland tissues. Ge inhibited MPO activity to reduce inflammatory cell infiltration during mastitis. ELISA and qPCR results for tissues and cells showed that the expression of TNF-α, IL-1β, and IL-6 was decreased and that of IL-10 was increased by Ge in a dose-dependent manner in mastitis. An analysis of protein phosphorylation was performed with sandwich ELISAs for both tissues and mMECs. The results showed that Ge significantly inhibited the phosphorylation of IκB, NF-κB p65, p38, ERK, and JNK, which was dramatically increased by LPS. These results demonstrate that Ge has an inhibitory effect on inflammation that protects mammary gland tis...Continue Reading

References

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Ruth N ZadoksYnte H Schukken
Oct 20, 2015·Journal of Receptor and Signal Transduction Research·Takahiro GojouboriMasatake Asano
Sep 16, 2018·Environmental Science and Pollution Research International·Oliver WicheHermann Heilmeier
May 3, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·David ChengRoland Stocker
Jun 13, 2019·Journal of Applied Genetics·Somayeh SharifiJames M Reecy
Sep 12, 2019·Journal of Agricultural and Food Chemistry·Yu ChenMeng-Yao Guo
Nov 22, 2019·Biological Trace Element Research·Yilei ZhangShiwen Xu

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Citations

Sep 22, 2020·World Journal of Gastroenterology : WJG·Ronald Neil KostoffDarla Roye Shores

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Methods Mentioned

BETA
confocal microscopy
ELISA
ELISAs

Software Mentioned

SPSS

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