Germinal center-dependent and -independent memory B cells produced throughout the immune response.

The Journal of Experimental Medicine
Charlotte ViantMichel C Nussenzweig

Abstract

Memory B cells comprise a heterogenous group of cells that differ in origin and phenotype. During the early phases of the immune response, activated B cells can differentiate into IgM-expressing memory cells, short-lived plasma cells, or seed germinal centers (GCs). The memory compartment is subsequently enriched by B cells that have been through several rounds of division and selection in the GC. Here, we report on the use of an unbiased lineage-tracking approach to explore the origins and properties of memory B cell subsets in mice with an intact immune system. We find that activated B cells continue to differentiate into memory B cells throughout the immune response. When defined on the basis of their origins, the memory B cells originating from activated B cells or GCs differ in isotype and overall gene expression, somatic hypermutation, and their affinity for antigen.

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Citations

Sep 30, 2021·The Journal of Experimental Medicine·Fahd Al QureshahDavid J Rawlings
Oct 13, 2021·Trends in Immunology·Kim L Good-Jacobson
Nov 27, 2021·Immunological Reviews·Juhee PaeGabriel D Victora
Dec 8, 2021·Nature Reviews. Immunology·Brian J Laidlaw, Ali H Ellebedy

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Software Mentioned

DeSeq2
R package sva
CellTrace
Ensembl
R package tximport
GraphPad Prism
kallisto
FortéBio
Seurat
GSEA

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