Germinal center reutilization by newly activated B cells.

The Journal of Experimental Medicine
Tanja A SchwickertMichel C Nussenzweig

Abstract

Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude that GCs are dynamic anatomical structures that can be reutilized by newly activated B cells during immune responses.

References

Jul 1, 1987·European Journal of Immunology·F G KroeseP Nieuwenhuis
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
May 1, 1996·The Journal of Experimental Medicine·M F BachmannR M Zinkernagel
Mar 16, 2002·Nature Immunology·Tien-An Yang ShihMichel C Nussenzweig
Jun 29, 2002·Cellular Immunology·B C SchaeferR M Kedl
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn Heltemes-HarrisTim Manser
Feb 6, 2004·Nature Immunology·Stefano CasolaKlaus Rajewsky
Nov 16, 2004·Nature Immunology·Randall L LindquistMichel C Nussenzweig
Aug 13, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Umesh S DeshmukhShu Man Fu
Mar 7, 2006·Current Opinion in Immunology·Takaharu Okada, Jason G Cyster
Dec 23, 2006·Science·Christopher D C AllenJason G Cyster
Feb 3, 2007·Nature·Tanja A SchwickertMichel C Nussenzweig
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaohe LiuTim Manser
Oct 17, 2007·The Journal of Experimental Medicine·Richard J BendeCarel J M van Noesel
Dec 3, 2008·The Journal of Experimental Medicine·Marc Thilo FiggeMichael Meyer-Hermann
Feb 3, 2009·Immunity·Ramon RoozendaalMichael C Carroll
Jun 10, 2009·The Journal of Experimental Medicine·Kazuhiro SuzukiJason G Cyster

❮ Previous
Next ❯

Citations

Jul 27, 2010·Transplantation Reviews·Ronald F ParsonsHooman Noorchashm
Dec 20, 2011·Nature Immunology·Agnès Lehuen, Nicolas Fazilleau
Nov 17, 2010·Nature Immunology·Masaki Hikada, Moncef Zouali
May 18, 2011·The Journal of Experimental Medicine·Tanja A SchwickertMichel C Nussenzweig
Mar 20, 2012·PloS One·Christopher M Collins, Samuel H Speck
Apr 8, 2014·Trends in Immunology·Franco Pissani, Hendrik Streeck
Jan 10, 2012·Annual Review of Immunology·Gabriel D Victora, Michel C Nussenzweig
Nov 11, 2014·The Journal of Clinical Investigation·Stéphanie SungaleeSandrine Roulland
Jul 9, 2010·Seminars in Immunopathology·Anja E HauserAnn M Haberman
Aug 4, 2010·The Journal of Experimental Medicine·Christopher SundlingGunilla B Karlsson Hedestam
Jun 4, 2013·Current Opinion in Immunology·Jean-Claude WeillClaude-Agnès Reynaud
Dec 2, 2015·Immunity·David Dominguez-SolaRiccardo Dalla-Favera
Apr 16, 2015·MAbs·Bernardo Cortina-CeballosJesús Martínez-Barnetche
Jan 21, 2012·Annals of the New York Academy of Sciences·Mats BemarkNils Y Lycke
Jul 20, 2010·Immunological Reviews·Raul ElguetaRandolph J Noelle
Jun 30, 2015·Scandinavian Journal of Immunology·K-P NeraO Lassila
Apr 19, 2016·Immunological Reviews·Andrea Reboldi, Jason G Cyster
Jul 10, 2013·Human Vaccines & Immunotherapeutics·Mohey Eldin El ShikhJohn G Tew
Apr 1, 2014·Current Opinion in Immunology·Gabriel D Victora, Luka Mesin
Jan 25, 2011·Molecular Immunology·Jacobus HendricksFrans G M Kroese
Feb 7, 2015·Nature Reviews. Immunology·Nilushi S De Silva, Ulf Klein
Feb 14, 2015·Nature Reviews. Immunology·Tomohiro KurosakiWataru Ise
Feb 3, 2015·Nature Immunology·Louise J McHeyzer-WilliamsMichael G McHeyzer-Williams
Sep 23, 2016·Immunity·Luka MesinGabriel D Victora
Jul 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jackson S TurnerIrina L Grigorova
Oct 28, 2011·Nature·Kerstin BererGurumoorthy Krishnamoorthy
Apr 13, 2019·Immunological Reviews·Erick Lu, Jason G Cyster
Jul 11, 2014·Nature Reviews. Cancer·David W Scott, Randy D Gascoyne
Jul 23, 2020·Scandinavian Journal of Immunology·Cecilia Fahlquist Hagert, Søren E Degn
May 31, 2017·International Journal of Rheumatic Diseases·Jing HeZhanguo Li
Apr 4, 2019·Frontiers in Immunology·Francesca MantileAntonella Prisco
Apr 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pia DosenovicMichel C Nussenzweig

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

MegAlign

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.