Germinal centres and the B cell system. IV. Functional characteristics of rabbit appendix germinal centre (-derived) cells

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
D OpsteltenP Nieuwenhuis

Abstract

Functional capacities of rabbit appendix germinal centre cells were tested in appendectomized, 450 rads X-irradiated rabbits, reconstituted with autologous appendix germinal centre cells, which are obtained by mechanical separation--"stripping"--of the appendix. For comparison, functional capacities of appendix germinal centre derived cells were tested in rabbits, 450 rads X-irradiated with the appendix shielded. In both types of experimental systems, slow restoration of primary IgM responsiveness to Salmonella Java paratyphi-B (PAR) was observed; in contrast, the capacity for memory cell production (of both mu and gamma-type) to PAR was restored very early in both systems. These results suggest germinal centres to be antigen dependent microenvironments for selective as well as non-selective amplification of immature B cells, which after subsequent maturation become part of the pool of either memory or virgin mature B cells respectively.

References

Jun 1, 1978·The Journal of Experimental Medicine·J AnderssonF Melchers
Jan 1, 1977·Immunological Reviews·G J NossalB L Pike
May 1, 1976·Cellular Immunology·P Nieuwenhuis, W L Ford
Feb 1, 1975·Cellular Immunology·N Donnelly, D H Sussdorf
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·B A AskonasB E Wright
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D van der HeijdenP Nieuwenhuis

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Citations

Nov 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·V I Nozdrin, S M Subbotin
Jul 1, 1987·European Journal of Immunology·F G KroeseP Nieuwenhuis
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D van der HeijdenP Nieuwenhuis
Jul 1, 1984·The American Journal of Anatomy·P Nieuwenhuis, D Opstelten
Apr 1, 1992·Immunological Reviews·P NieuwenhuisH G Seijen

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