Germinated soy germ with increased soyasaponin Ab improves BMP-2-induced bone formation and protects against in vivo bone loss in osteoporosis

Scientific Reports
Chan-Woong ChoiWoo-Duck Seo

Abstract

Osteoporosis is frequently induced following menopause, and bone fractures result in serious problems including skeletal deformity, pain, and increased mortality. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aimed to clarify the bone protecting effects of germinated soy germ extracts (GSGE) and their mode of action. GSGE increased expression of alkaline phosphatase (ALP) and osteocalcin (OCL) by stimulating the expression of runt-related transcription factor 2 (Runx2) and osterix (Osx) through activation of Smad signaling molecules. Furthermore, germination of soy germ increased levels of nutritional components, especially soyasaponin Ab. The anabolic activity of soyasaponin Ab in GSGE was also evaluated. GSGE and soyasaponin Ab significantly protected against ovariectomy (OVX)-induced bone loss and improved bone-specific alkaline phosphatase (BALP) level in mouse serum. These in vitro and in vivo study results demonstrated that GSGE and soyasaponin Ab have potential as therapeutic candidate agents for bone protection in postmenopausal osteoporosis.

References

Mar 6, 1999·The Journal of Biological Chemistry·H HaradaM Nakatsuka
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·J A CauleyUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 23, 2003·The Journal of Nutritional Biochemistry·Xiaowei ChenJohn J B Anderson
Mar 24, 2005·Journal of Cellular Biochemistry·Ayse B CelilPhil G Campbell
Jun 7, 2005·Developmental Biology·Zhousheng XiaoLeigh Darryl Quarles
Jun 30, 2005·Experimental Biology and Medicine·Sun-Ok LeeSuzanne Hendrich
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·D L FrenchC E Webber
Dec 9, 2008·Bioscience, Biotechnology, and Biochemistry·Saori TakahashiSeihan Yamada
Sep 21, 2010·European Journal of Pharmacology·Chih-Hsin TangJu-Fang Liu
Nov 22, 2011·The Journal of Biological Chemistry·Won-Gu JangJeong-Tae Koh
Feb 3, 2012·International Journal of Biological Sciences·Guiqian ChenYi-Ping Li
Nov 6, 2012·Food Chemistry·Sun-Lim KimIll-Min Chung

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Citations

May 24, 2019·International Journal of Molecular Sciences·Vrathasha VrathashaAnja Nohe
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shin-Hye KimMi-Ja Lee
Jan 27, 2019·Food & Function·Han-Jun KimSun Hee Do
Jun 3, 2021·Nutrients·Wojciech SłupskiBeata Nowak
Nov 30, 2021·Journal of Agricultural and Food Chemistry·Ping S YatesBao-Hua Song

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Methods Mentioned

BETA
hormone replacement therapy
PCR
NMR
ELISA
protein assay
enzyme-linked immunosorbent assay

Software Mentioned

Visus
CyberMed

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