Germinoma: unusual imaging and pathological characteristics. Report of two cases

Journal of Neurosurgery
Elisabeth J RushingMariarita Santi

Abstract

Primary germ cell neoplasms of the central nervous system typically develop as midline mass lesions during the first three decades of life. The authors present two cases with atypical clinicopathological features that stimulate discussion on the diagnosis and management of these tumors. The first patient was an 11-year-old boy of Japanese-American heritage who presented with a 6-month-long history of cognitive decline, difficulty swallowing, unsteady gait, and intermittent right-sided posturing. The initial magnetic resonance (MR) image of the brain displayed a mildly increased T2 signal in the cerebral peduncles, putamen, and globus pallidus bilaterally. Follow-up MR images showed an increase in the T2 signal abnormality in the left basal ganglia. The second patient was a 10-year-old Caucasian boy who presented with diabetes insipidus and subsequently displayed progressive fatigue, involuntary eye and mouth movements, and obsessive-compulsive behavior. An MR image demonstrated signs of mineral deposition and foci of increased T2 signal in both basal ganglia. Follow-up MR images demonstrated a progressive increase in the T2 signal (which was then located within the mesial temporal lobe). A biopsy performed on the left thalamic ...Continue Reading

Citations

Mar 20, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Nobuyuki KawaiTakashi Tamiya
Apr 1, 2010·European Child & Adolescent Psychiatry·Juan UndurragaM L Lázaro
Jan 12, 2013·Brain Tumor Pathology·Kazutaka SugimotoMichiyasu Suzuki
Mar 29, 2012·Journal of Psychiatry & Neuroscience : JPN·Leonardo F FontenelleMurat Yücel
Feb 26, 2013·Journal of Neurosurgery. Pediatrics·Megha MadhukarMark S Dias

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