Germline ATBF1 mutations and prostate cancer risk

The Prostate
Junyan XuWilliam B Isaacs

Abstract

ATBF1 has been recently identified as a candidate prostate tumor suppressor gene. In addition to more unique mutations, two somatic mutations (shortening of a polypyrimidine tract [Poly(T)n] and a deletion beginning at codon 3381 (3381del)) were each observed in multiple prostate cancer samples and both appear to have an impact on ATBF1 gene function and expression. We assayed two recurrent sequence variants in germline DNA from prostate cancer cases and controls, and examined whether carriers of these variants are at increased risk for prostate cancer. We found Poly(T)n variants in both normal and matched tumor DNA samples from multiple patients, indicating a germline origin in each case. Genotyping germline DNA samples indicated that 3381del was significantly associated with prostate cancer risk among sporadic cases (P = 0.03), but not among men with hereditary disease. Our study indicates that the germline 3381del allele may influence prostate cancer susceptibility.

References

Oct 1, 1995·Japanese Journal of Cancer Research : Gann·H SuzukiJ Shimazaki
May 13, 1999·The Journal of Biological Chemistry·P KasparM Dvorák
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Toshiaki NinomiyaTaiki Tamaoki
Jun 28, 2002·Cancer Metastasis Reviews·J T Dong
Oct 1, 2003·The Prostate·Adrie van BokhovenM Scott Lucia

❮ Previous
Next ❯

Citations

Jul 28, 2011·JAMA : the Journal of the American Medical Association·Mohammed OrloffCharis Eng
Mar 8, 2008·The Prostate·Taija M Kiviharju-Af Hällström, Marikki Laiho
May 31, 2012·Genesis : the Journal of Genetics and Development·Xiaodong SunJin-Tang Dong
Aug 4, 2015·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Xiaodong SunJin-Tang Dong
Nov 9, 2017·Journal of Exercise Rehabilitation·Seung-Ae Yang
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yong Gu ChoWon Sang Park

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cancer Research and Clinical Oncology
Xiaodong SunJin-Tang Dong
International Journal of Cancer. Journal International Du Cancer
Yoshinori MoriTakashi Joh
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Yong Gu ChoW S Park
© 2022 Meta ULC. All rights reserved