Germline BRCA, chemotherapy response scores, and survival in the neoadjuvant treatment of ovarian cancer

BMC Cancer
Yong Jae LeeYoung Tae Kim

Abstract

To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS). We retrospectively reviewed the medical records of 169 high-grade serous ovarian cancer patients who underwent a germline BRCA1/2 test and received three cycles of NAC at the Yonsei Cancer Center from 2006 to 2018. Chemotherapy response scores were compared in patients with and without BRCA1/2 mutations. The effects of BRCA1/2 mutations and CRS on survival were evaluated. BRCA1/2 mutations were detected in 47 (28.1%) of the 169 patients. Overall, 16 (34.0%) patients with BRCA1/2 mutations had a CRS 3 to chemotherapy compared to scores of 43 in patients (35.2%) without a mutation. Response scores of 3 in patients with BRCA1/2 mutations were not significantly associated with either improved progression-free survival (PFS) (P = 0.949) or overall survival (OS) (P = 0.168). However, CRS 3 in patients without BRCA mutations was significantly associated with both improved PFS (P = 0.030) and OS (P = 0.039). In patients with CRS1/2, carriers of BRCA1/2 mutations had better PFS (P = 0.034...Continue Reading

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Citations

Jun 11, 2020·Journal of Gynecologic Oncology·Sean Kehoe
Nov 3, 2020·Critical Reviews in Oncology/hematology·Riccardo Ponzone
Oct 16, 2020·Journal of Clinical Laboratory Analysis·Miaomiao YeXueqiong Zhu
Feb 11, 2021·Cancers·Ami PatelNicole D Fleming

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Methods Mentioned

BETA
pancreatectomy

Software Mentioned

Sequencher
SPSS

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