Germline determinants of clinical outcome of cutaneous melanoma

Pigment Cell & Melanoma Research
Matjaz VogelsangTomas Kirchhoff

Abstract

Cutaneous melanoma (CM) is the most lethal form of skin cancer. Despite the constant increase in melanoma incidence, which is in part due to incremental advances in early diagnostic modalities, mortality rates have not improved over the last decade and for advanced stages remain steadily high. While conventional prognostic biomarkers currently in use find significant utility for predicting overall general survival probabilities, they are not sensitive enough for a more personalized clinical assessment on an individual level. In recent years, the advent of genomic technologies has brought the promise of identification of germline DNA alterations that may associate with CM outcomes and hence represent novel biomarkers for clinical utilization. This review attempts to summarize the current state of knowledge of germline genetic factors studied for their impact on melanoma clinical outcomes. We also discuss ongoing problems and hurdles in validating such surrogates, and we also project future directions in discovery of more powerful germline genetic factors with clinical utility in melanoma prognostication.

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Citations

Dec 18, 2018·Molecular Carcinogenesis·Mariusz L HartmanMalgorzata Czyz
Jan 27, 2019·Melanoma Research·Vivien MarasiganMarjan Garmyn
Jan 7, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matjaz VogelsangTomas Kirchhoff

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