Germline Modification and Engineering in Avian Species

Molecules and Cells
Hong Jo LeeJae Yong Han

Abstract

Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies.

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Citations

Oct 27, 2017·International Journal of Molecular Sciences·Hong Jo LeeJae Yong Han
Feb 10, 2018·Journal of Animal Science and Biotechnology·Jae Yong Han, Young Hyun Park
Aug 24, 2017·Scientific Reports·Xiaogang CuiHong-Xiang Liu
Oct 21, 2021·Biology of Reproduction·Nima DehdilaniHesam Dehghani

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Methods Mentioned

BETA
transgenic
gene knockout

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