Germline stem cells and follicular renewal in the postnatal mammalian ovary

Nature
Joshua JohnsonJonathan L Tilly

Abstract

A basic doctrine of reproductive biology is that most mammalian females lose the capacity for germ-cell renewal during fetal life, such that a fixed reserve of germ cells (oocytes) enclosed within follicles is endowed at birth. Here we show that juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oocyte degeneration (atresia) and clearance, are needed to continuously replenish the follicle pool. Consistent with this, treatment of prepubertal female mice with the mitotic germ-cell toxicant busulphan eliminates the primordial follicle reserve by early adulthood without inducing atresia. Furthermore, we demonstrate cells expressing the meiotic entry marker synaptonemal complex protein 3 in juvenile and adult mouse ovaries. Wild-type ovaries grafted into transgenic female mice with ubiquitous expression of green fluorescent protein (GFP) become infiltrated with GFP-positive germ cells that form follicles. Collectively, these data establish the existence of proliferative germ cells that sustain oocyte and follicle production in the postnatal mammalian ovary.

References

Aug 1, 1976·The Journal of Experimental Zoology·M J FaddyR G Edwards
Dec 1, 1987·The Journal of Clinical Endocrinology and Metabolism·S J RichardsonJ F Nelson
Aug 6, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Peters
Oct 1, 1971·Mutation Research·W M GenerosoS W Huff
Sep 1, 1965·Experimental Cell Research·M CroneH Peters
Apr 1, 1980·Toxicology and Applied Pharmacology·D R Mattison
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R L Brinster, J W Zimmermann
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y FujiwaraT Noce
Nov 1, 1996·The Journal of Cell Biology·A F Davis, D A Clayton
Jan 1, 1997·Annual Review of Genetics·H Lin
Dec 29, 1998·Mechanisms of Development·A K HadjantonakisA Nagy
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D WalpitaT Ashley
Aug 30, 2000·Molecular and Cellular Endocrinology·M J Faddy
Jun 9, 2001·Developmental Biology·M E Pepling, A C Spradling
Sep 22, 2001·Cell Structure and Function·T NoceN Tsunekawa
Nov 2, 2001·Nature·A SpradlingT Kai
Nov 21, 2001·Nature Reviews. Molecular Cell Biology·J L Tilly
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P E Cohen, J W Pollard
Dec 3, 2002·Nature Reviews. Genetics·Haifan Lin
Dec 20, 2002·Journal of Anatomy·Jonathan G D Foley, Jonathan B L Bard
Mar 21, 2003·Reproductive Biology and Endocrinology : RB&E·Jonathan L Tilly
Apr 4, 2003·Biology of Reproduction·Clayton J BrinsterKyle E Orwig
Apr 15, 2003·Experimental Hematology·Stephen J SzilvassyConnie J Eaves
Jul 30, 2003·The Journal of Cell Biology·Yvan TorrenteNereo Bresolin
Sep 1, 1961·Experimental Cell Research·K BORUM
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider

❮ Previous
Next ❯

Citations

May 31, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Sabine Hombach-KlonischMarek Los
Jul 12, 2005·Journal of Molecular Evolution·Sara A Sandstedt, Priscilla K Tucker
Jul 3, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kerong ShiNing Li
May 20, 2005·Cell and Tissue Research·Barbara C Vanderhyden
Jun 29, 2005·Cell and Tissue Research·Ann E Drummond
Mar 31, 2011·Molecules and Cells·Sungtae Kim, Juan Carlos Izpisua Belmonte
Jul 16, 2008·Apoptosis : an International Journal on Programmed Cell Death·Dmitri V KryskoKatharina D'Herde
Feb 11, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H Ayse ParlakgumusAlper Parlakgumus
May 4, 2005·Fertility and Sterility·Douglas R DanforthChad I Friedman
Jun 14, 2005·Current Opinion in Genetics & Development·Rongwen XiTing Xie
Apr 20, 2005·Molecular and Cellular Endocrinology·Paul M WassarmanEveline S Litscher
Apr 20, 2005·Molecular and Cellular Endocrinology·Poul Erik HøyerKjeld Møllgård
Oct 3, 2013·Reproductive Biomedicine Online·Roger G Gosden
Apr 10, 2010·The Behavioral and Brain Sciences·David A Coall, Ralph Hertwig
May 5, 2005·Psychological Bulletin·Lawrence V Harper
Nov 5, 2004·Nature
Nov 5, 2004·Nature·Kendall Powell
Aug 5, 2005·Nature·Claire Ainsworth
May 30, 2012·Cell Research·Ying GuJuan Carlos Izpisua Belmonte
Jun 10, 2005·Nature·S D HatfieldH Ruohola-Baker
Mar 28, 2006·Nature Cell Biology·Paul W DyceJulang Li
Nov 23, 2006·Nature Cell Biology·Rabindranath De La FuenteKathrin Muegge
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Hiroshi Kubota, Ralph L Brinster
Oct 7, 2004·Nature Genetics·Augustine KongKari Stefansson
Mar 8, 2012·Nature Medicine·Evelyn E Telfer, David F Albertini
Nov 8, 2008·Nature Medicine·Martin M Matzuk, Dolores J Lamb
Sep 8, 2005·Nature Medicine·Kendall Powell
Nov 8, 2008·Nature Medicine·Teresa K Woodruff
Oct 30, 2013·Nature Reviews. Endocrinology·Jacques Donnez, Marie-Madeleine Dolmans
Aug 15, 2013·Nature Reviews. Molecular Cell Biology·Dean Clift, Melina Schuh
Nov 4, 2006·Cell Death and Differentiation·V HanouxG Livera
Jan 5, 2006·European Journal of Human Genetics : EJHG·Marcus E PembreyUNKNOWN ALSPAC Study Team
Oct 28, 2008·Seminars in Reproductive Medicine·Tannaz ToloubeydokhtiNasser Chegini
Aug 2, 2005·Seminars in Reproductive Medicine·Michelle Jamnongjit, Stephen R Hammes
Jul 8, 2005·The New England Journal of Medicine·Rogerio A Lobo
Dec 17, 2009·Reproduction, Fertility, and Development·Mario Binelli, Bruce D Murphy
Sep 8, 2012·Reproduction, Fertility, and Development·Nivia Rocio Antonio-RubioNorma Moreno-Mendoza
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hua ZhangKui Liu
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lei Lei, Allan C Spradling
Feb 24, 2005·Stem Cells and Development·Boon Chin HengSoon Chye Ng

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