Germline variation of TNFAIP3 in primary Sjögren's syndrome-associated lymphoma

Annals of the Rheumatic Diseases
Gaetane NocturneXavier Mariette

Abstract

A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort. We aimed to replicate this association. The rs2230926 polymorphism was genotyped in cases and controls of European ancestry from two independent cohorts from UK and France. Case control association tests were performed (Fisher's test) in the two cohorts, followed by a meta-analysis of the two cohorts. The UK cohort included 308 controls and 590 patients with pSS including 31 with a history of lymphoma. The French cohort consisted of 448 controls and 589 patients with pSS including 47 with lymphoma. In both cohorts, the rs2230926 missense polymorphism was not associated with pSS. However, in the UK cohort, the rs2230926G variant was significantly associated with pSS-associated lymphoma (OR=2.74, 95% CI (1.07 to 7.03), p=0.0423, compared with patients with pSS without lymphoma, and OR=3.12, 95% CI (1.16 to 8.41), p=0.0314, compared with healthy controls) as observed in the French cohort. The meta-analysis of the two cohorts confirmed these results (OR=2.48, 95% CI (1.87 to 3.28) p=0.0037 and OR...Continue Reading

References

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Citations

Feb 21, 2018·Biomarkers in Medicine·Chiara BaldiniStefano Bombardieri
Mar 7, 2019·Rheumatology·Gaetane NocturneXavier Mariette
Jun 28, 2016·F1000Research·Nicholas Holdgate, E Wiliam St Clair
Feb 9, 2018·Nature Reviews. Rheumatology·Gaëtane Nocturne, Xavier Mariette
May 1, 2017·Clinical Reviews in Allergy & Immunology·Taher E TaherRizgar A Mageed
May 1, 2018·Frontiers in Medicine·Alessia AlunnoFrancesco Carubbi
Jul 24, 2020·Journal of Clinical Medicine·Dorian ParisisChristine Delporte
Jan 22, 2019·Journal of Immunology Research·Adrianos NezosClio P Mavragani
Dec 2, 2020·Journal of Clinical Medicine·Ioanna E StergiouMichael Voulgarelis
Jan 23, 2021·Expert Review of Clinical Immunology·Loukas ChatzisAndreas V Goules
Mar 13, 2021·Frontiers in Immunology·Guillaume PadernYves-Marie Pers
Apr 9, 2021·Ocular Immunology and Inflammation·Zujaja TauqeerMina Massaro-Giordano
Apr 28, 2019·La Revue de médecine interne·G Nocturne

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