PMID: 2506844Jul 1, 1989Paper

Gerontopsychological studies using NAI ('Nürnberger Alters-Inventar') on patients with organic psychosyndrome (DSM III, Category 1) treated with centrophenoxine in a double blind, comparative, randomized clinical trial

Archives of Gerontology and Geriatrics
G PékI Zs-Nagy

Abstract

A double blind clinical trial was performed on 50 persons (25 men, 25 women) over the age 60 (average age: 77 years). They suffered from dementias of medium level (DSM III, Category 1, ICD No. 299), and had been residents in an old age home longer than 3 months at the start of the trial. The patients were treated first for 2 weeks by placebo tablets and their initial performance was recorded during this period by using the Nuremberg Gerontopsychological Inventory (NAI). This was then followed by a treatment for 8 weeks with the nootropic drug, centrophenoxine (CPH), the dose of which was 2 g/day distributed in 2 x 2 tablets of Helfergin500 (Promonta, Hamburg, FRG), or with placebo tablets of identical size, then the NAI test was repeated again. Verum or placebo treatment was selected randomly and the code was revealed only after having elaborated all the results of the trial. During the treatment period four drop-outs occurred for intercurrent diseases. Evaluation was based on a semi-quantitative, intra-individual comparison of the performance before and after treatment. The results obtained suggest that CPH treatment may be useful in dementias of medium level in quite old groups of patients, since 48% of the verum group displa...Continue Reading

References

Feb 1, 1979·Mechanisms of Ageing and Development·I Zs-Nagy
Nov 21, 1978·Journal of Theoretical Biology·I Zs-Nagy
Jan 1, 1989·Archives of Gerontology and Geriatrics·S DamjanovichB Somogyi
Dec 1, 1985·Archives of Gerontology and Geriatrics·W D Oswald, U M Fleischmann
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Aug 1, 1973·Experimental Gerontology·R Hochschild
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Dec 1, 1982·Archives of Gerontology and Geriatrics·C Bertoni-FreddariC Pieri

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Citations

Mar 1, 1991·Archives of Gerontology and Geriatrics·I Zs -Nagy
Nov 1, 1991·Neurobiology of Aging·T J Collier, P D Coleman
Jun 21, 2001·Il Farmaco·A Sparatore, F Sparatore
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Betty Yuen Kwan LawVincent Kam Wai Wong
Jan 1, 1994·Archives of Gerontology and Geriatrics·R PopaR Mateescu
Jun 30, 1994·Annals of the New York Academy of Sciences·F SchneiderR Mateescu
May 7, 1999·Journal of Geriatric Psychiatry and Neurology·B R Ott, N J Owens
Mar 1, 2005·European Journal of Ageing·Matthias Kliegel, Daniel Zimprich
Aug 8, 2013·Nature Medicine·Ralph A Nixon
Jun 30, 1994·Annals of the New York Academy of Sciences·V PredescuL Botezat-Antonescu

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