Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease

Aging
Alexey MoskalevAlex Zhavoronkov

Abstract

As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors (http://geroprotectors.org). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database f...Continue Reading

References

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Citations

Jul 23, 2016·Oncotarget·Vicky LutchmanVladimir I Titorenko
Aug 8, 2017·Aging·Diogo G BarardoAlex A Freitas
Jan 18, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Polina MamoshinaAlex Zhavoronkov
May 30, 2020·Nature Reviews. Drug Discovery·Linda PartridgeBrian K Kennedy
Mar 17, 2017·Aging Cell·Diogo BarardoJoão Pedro de Magalhães
Mar 7, 2019·BMC Systems Biology·Alexey MoskalevMikhail Shaposhnikov
Feb 11, 2020·Frontiers in Cell and Developmental Biology·Harikrishnan Thoppil, Karl Riabowol
Jun 6, 2017·Aging and Disease·Alexey MoskalevMikhail Shaposhnikov
Jul 1, 2018·Aging Cell·Handan Melike DönertaşJanet M Thornton
Dec 12, 2019·Expert Opinion on Drug Discovery·Alexey Moskalev
Aug 18, 2020·Aging·Alexander M AliperAndreyan N Osipov
Jun 9, 2017·Oxidative Medicine and Cellular Longevity·Younes MedkourVladimir I Titorenko
Nov 23, 2017·Aging·Alexander AliperAlex Zhavoronkov
Jan 28, 2021·International Journal of Molecular Sciences·Anton Y KulagaRobi Tacutu
Feb 1, 2021·Ageing Research Reviews·Alexander S SokolovAlexey A Moskalev
Jan 8, 2021·Biological Trace Element Research·Yuri V NikitchenkoAnatoly I Bozhkov
Sep 10, 2020·Mechanisms of Ageing and Development·Agnieszka ZajdaMagdalena Markowicz-Piasecka
Dec 4, 2020·Aging and Disease·Alexey MoskalevCalogero Caruso
Aug 5, 2021·Aging Cell·Cyril StatzerCollin Y Ewald
Aug 11, 2021·Oxidative Medicine and Cellular Longevity·Daniela GradinaruAlexander Bürkle
Aug 24, 2018··Hafez Eslami ManoochehriJavad Birjandtalab

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Methods Mentioned

BETA
L1000

Software Mentioned

LS
JenAge
Lifespan

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