Gestational 30% and 40% fat diets increase brain GLUT2 and neuropeptide Y immunoreactivity in neonatal Wistar rats

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Marlon E CerfJohan Louw

Abstract

Adverse maternal nutrition induces developmental programming in progeny thereby predisposing them to metabolic disease. The aim of the study was to determine whether maternal diets, with varying fat percentages as energy, alter the expression of factors associated with brain glucose sensing (glucose transporter 2 and glucokinase) and the feeding response (neuropeptide Y and leptin). Pregnant dams were maintained on diets of 10% (control), 20% (20F), 30% (30F) and 40% (40F) fat as energy throughout gestation. In 1-day-old neonatal offspring, anthropometric measurements were recorded. Whole neonatal brain was rapidly excised, weighed and either snap-frozen at -80°C for quantitative RT-PCR or fixed in formalin for immunohistochemical analysis. Brain glucose transporter 2, glucokinase, neuropeptide Y and leptin mRNA expression and immunoreactivity were determined in neonates. In the 20F neonates increases in body weight, head circumference and crown to rump length concomitant with reduced glucokinase immunoreactivity were found. The 30F neonates displayed increases in body weight, head length, head width, crown to rump length and immunoreactivity for both glucose transporter 2 and neuropeptide Y. The 40F neonates also demonstrated ...Continue Reading

References

Sep 11, 1991·The Journal of Clinical Investigation·C J GreenbaumL J Klaff
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Y KagotaniK Chihara
Jun 11, 1984·Brain Research·J M AllenS R Bloom
Apr 1, 1996·The Journal of Laboratory and Clinical Medicine·D P FiglewiczD Porte
Mar 13, 1998·The American Journal of Clinical Nutrition·D B West, B York
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Feb 18, 1999·Molecular and Cellular Biology·S P GygiR Aebersold
Jul 28, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D G BaskinM W Schwartz
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C H KimK U Lee
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P GygiR Aebersold
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·R S Ahima, J S Flier
Jan 13, 2001·Brain Research. Developmental Brain Research·R KozakB Beck
Dec 18, 2001·Experimental Biology and Medicine·M W Schwartz
Jan 26, 2002·British Medical Bulletin·A M Prentice
Apr 10, 2003·Biochemical and Biophysical Research Communications·Fabrice BertileThierry Raclot
Apr 17, 2003·Endocrinology·Naira GorovitsMaureen J Charron
Jun 26, 2003·Brain Research. Molecular Brain Research·Xu-Feng HuangLen H Storlien
Jul 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sheng BiTimothy H Moran
Jul 1, 2004·The Journal of Nutrition·Vivienne M MooreJeffrey S Robinson
Jul 9, 2004·Pediatric Research·Peter D Gluckman, Mark A Hanson
Feb 12, 2005·The Journal of Physiology·I Caroline McMillenBeverly S Mühlhäusler
Jul 28, 2005·American Journal of Physiology. Endocrinology and Metabolism·Christopher D MorrisonMichael W Schwartz
Sep 17, 2005·Journal of Internal Medicine·C Broberger
Feb 14, 2006·The British Journal of Nutrition·Marlon E CerfSonia A Wolfe-Coote
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Beck
Sep 5, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M J MorrisD Cameron-Smith
Dec 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Elena ValassiFrancesco Cavagnini
Dec 25, 2007·Plant Foods for Human Nutrition·Nerissa VaughnElvira Gonzalez de Mejia
Dec 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B Thorens
Jul 7, 2009·American Journal of Obstetrics and Gynecology·Patricia M DietzAndrea J Sharma

❮ Previous
Next ❯

Citations

Jun 14, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kinning PoonSarah F Leibowitz
Nov 12, 2013·Nutrition·Luiz Felipe BarellaPaulo Cezar de Freitas Mathias
Oct 11, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Olufadekemi T Kunle-AlabiYinusa Raji
Apr 18, 2019·Reproductive Biology and Endocrinology : RB&E·Julian K ChristiansRaajan Garcha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.