PMID: 3753753Jan 1, 1986Paper

Gestational age-dependent changes in plasma inositol levels and surfactant composition in the fetal rat

Pediatric Research
J Egberts, W A Noort

Abstract

To study the possibility that changes in fetal surfactant composition depend on the availability of inositol, we isolated surfactant material from lungs of fetal and neonatal rats and estimated their plasma inositol concentration. During the 18- to 22-day gestational period the amount of surfactant increases from 0.17 to 3.10 mumol phospholipids/g wet lung. From day 20 onward, 70% or more of the phospholipids is phosphatidylcholine. In this period the relatively high percentage of phosphatidylinositol (8%) in the lung surfactant decreases to 4% whereas the percentage of phosphatidylglycerol increases from 2 to 8% at parturition. During gestation the phospholipid/protein ratio of the surfactant material increase from 3 to 11 and the highest ratio is found immediately after birth. It decreases again 24 h after birth to values characteristic for surfactant from adult rats. The plasma inositol concentration drops during the 18- to 22-day period from 0.81 to 0.26 mmol/liter and a similar decrease in inositol concentration occurs in amniotic fluids. The phosphatidylglycerol/phosphatidylinositol ratio of surfactant correlated negatively with the fetal plasma inositol concentration. It is most likely that the reduction in the level of ...Continue Reading

Citations

Sep 12, 1986·Biochimica Et Biophysica Acta·J EgbertsA A Boonman
Jun 15, 1988·Biochimica Et Biophysica Acta·J J BatenburgW Klazinga
Apr 8, 1999·Progress in Lipid Research·J J Batenburg, H P Haagsman
Oct 28, 2003·American Journal of Respiratory Cell and Molecular Biology·Gunnar A RauWolfgang Bernhard
Jul 10, 2019·The Cochrane Database of Systematic Reviews·Alexandra HowlettNishad Plakkal
May 1, 2015·The Cochrane Database of Systematic Reviews·Alexandra HowlettNishad Plakkal
Jun 9, 1988·Biochimica Et Biophysica Acta·M Post, L M van Golde

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