Gestational age-dependent expression of insulin-like growth factor-binding protein-1 (IGFBP-1) phosphoisoforms in human extraembryonic cavities, maternal serum, and decidua suggests decidua as the primary source of IGFBP-1 in these fluids during early pregnancy

The Journal of Clinical Endocrinology and Metabolism
N A MartinaL C Giudice

Abstract

The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are important regulators of fetal and maternal tissue development during pregnancy. Posttranslational modification of IGFBP-1 yields up to six IGFBP-1 phosphovariants and a nonphosphorylated form, which in vitro, have some different properties. Nonphospho IGFBP-1 has less affinity for IGFs than the phospho isoforms and also may have IGF-independent actions. Herein, we have investigated the complement of IGFBP-1 phosphoisoforms present in extraembryonic coelomic (EEC) fluid, amniotic fluid (AF), and maternal serum (MS) throughout human gestation. Also, to determine potential tissue source(s) of IGFBP-1 in these fluids, we have quantified IGFBP-1 and examined IGFBP-1 phosphoisoforms in conditioned media (CM) from maternal decidua, fetal liver, and fetal kidney explants throughout gestation. Western immunodetection revealed that IGFBP-1, present in EEC and AF in early pregnancy and in CM from early pregnancy decidua, is primarily in the nonphosphorylated form. MS in this period contains primarily the nonphospho form and, as in nonpregnant adults, the highly phosphorylated form of IGFBP-1. The phosphorylation profile of IGFBP-1 in AF, MS, and decidua CM chan...Continue Reading

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Citations

Aug 7, 2002·The Journal of Clinical Investigation·Paul A CrosseyJohn P Miell
Feb 16, 2015·Journal of Cell Communication and Signaling·Madhulika B Gupta
Dec 20, 2014·Archives of Gynecology and Obstetrics·Katarzyna Kosinska-KaczynskaMiroslaw Wielgos
May 10, 2015·Molecular and Cellular Endocrinology·Niyati MalkaniMadhulika B Gupta
Nov 20, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L RahkonenJ Paavonen
Aug 15, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·B Martinez de TejadaO Irion
Aug 4, 2006·Clinical Obstetrics and Gynecology·Joan M G Crane
Mar 7, 2007·Gynecologic and Obstetric Investigation·Derya ErogluEsra Kuscu
Nov 27, 2018·Biology of Reproduction·Madhulika B Gupta, Thomas Jansson

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