Gestational and early postnatal hypothyroidism alters VGluT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats

Frontiers in Neuroanatomy
Daniela NavarroP Berbel

Abstract

Thyroid hormones are fundamental for the expression of genes involved in the development of the CNS and their deficiency is associated with a wide spectrum of neurological diseases including mental retardation, attention deficit-hyperactivity disorder and autism spectrum disorders. We examined in rat whether developmental and early postnatal hypothyroidism affects the distribution of vesicular glutamate transporter-1 (VGluT1; glutamatergic) and vesicular inhibitory amino acid transporter (VGAT; GABAergic) immunoreactive (ir) boutons in the hippocampus and somatosensory cortex, and the behavior of the pups. Hypothyroidism was induced by adding 0.02% methimazole (MMI) and 1% KClO4 to the drinking water starting at embryonic day 10 (E10; developmental hypothyroidism) and E21 (early postnatal hypothyroidism) until day of sacrifice at postnatal day 50. Behavior was studied using the acoustic prepulse inhibition (somatosensory attention) and the elevated plus-maze (anxiety-like assessment) tests. The distribution, density and size of VGluT1-ir and VGAT-ir boutons in the hippocampus and somatosensory cortex was abnormal in MMI pups and these changes correlate with behavioral changes, as prepulse inhibition of the startle response ampl...Continue Reading

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Citations

Mar 5, 2016·Frontiers in Endocrinology·Julieta E LischinskyJoanne Rovet
Jun 9, 2016·The Journal of Pediatrics·Sarah E Cusick, Michael K Georgieff
Apr 22, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonio Ortega-ÁlvaroJorge Manzanares
Jan 25, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ayda TavitianHyman M Schipper
Jul 3, 2020·Endocrinology·Mary E GilbertMarta Axelstad
Nov 6, 2015·Frontiers in Endocrinology·Sarah M WheelerJoanne F Rovet
Nov 25, 2018·Psychopharmacology·V Echeverry-AlzateJ A López-Moreno
Aug 4, 2019·International Journal of Environmental Research and Public Health·Gang ChengYan Yan
Nov 7, 2019·Frontiers in Neurology·Wenjun WangXiang Li
Oct 28, 2020·Environmental Science and Pollution Research International·Hemangini A DhaibarPushpa Robin
Nov 25, 2019·Molecular and Cellular Endocrinology·Katherine L O'Shaughnessy, Mary E Gilbert
Jul 22, 2018·Molecular and Cellular Endocrinology·Juliana Tonietto DominguesAriane Zamoner

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

Leica LCS Lite
Image J
STARTLE
ImageJ
VGluT1
VGAT
SYSTAT

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