Gestational and postnatal low protein diet alters insulin sensitivity in female rats

Experimental Biology and Medicine
Kally J BerlezeMarcos L S Perry

Abstract

Nutrition during pregnancy and lactation can program an offspring's metabolism with regard to glucose and lipid homeostasis. A suboptimal environment during fetal, neonatal and infant development is associated with impaired glucose tolerance, type 2 diabetes and insulin resistance in later adult life. However, studies on the effects of a low protein diet imposed from the beginning of gestation until adulthood are scarce. This study's objective was to investigate the effects of a low protein diet imposed from the gestational period until 4 months of age on the parameters of glucose tolerance and insulin responsiveness in Wistar rats. The rats were divided into a low protein diet group and a control group and received a diet with either 7% or 25% protein, respectively. After birth, the rats received the same diet as their mothers, until 4 months of age. In the low protein diet group it was observed that: (i) the hepatic glycogen concentration and hepatic glycogen synthesis from glycerol were significantly greater than in the control group; (ii) the disposal of 2-deoxyglucose in soleum skeletal muscle slices was 29.8% higher than in the control group; (iii) there was both a higher glucose tolerance in the glucose tolerance test; a...Continue Reading

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Citations

Mar 23, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fernanda R C L AlmeidaHélio Chiarini-Garcia
Feb 18, 2016·Annals of the New York Academy of Sciences·Tsang-hai Huang, Gene P Ables
Dec 20, 2014·Neuroscience and Biobehavioral Reviews·Matthew W HaleLuba Sominsky
Dec 11, 2014·Neurochemical Research·Luis Valmor PortelaAlexandre Pastoris Muller
Feb 5, 2015·The Journal of Physiological Sciences : JPS·Fatemeh BagheripuorAsghar Ghasemi
Nov 25, 2016·BioMed Research International·Mingxin LiJingming Dong

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