Gestational diabetes has no additional effect on plasma thrombin-activatable fibrinolysis inhibitor antigen levels beyond pregnancy

Diabetes Research and Clinical Practice
Baris AkinciSena Yesil

Abstract

Pregnancy is a prothrombotic condition with increased levels of several circulating coagulation factors. Decreased fibrinolytic activity has been shown in gestational diabetes. Gestational diabetes has been found to be associated with higher plasma plasminogen activator inhibitor-1 (PAI-1) antigen levels than normal pregnancy. The aim of the present study is to investigate the effect of gestational diabetes on plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels. Plasma TAFI and PAI-1 antigen levels were measured in 26 pregnant women with gestational diabetes, 25 pregnant women with normal glucose tolerance, and age-matched 24 non-pregnant women with no history of gestational diabetes. Increased plasma TAFI antigen levels were found in pregnant women compared to non-pregnant controls. However, no statistically significant difference in TAFI antigen levels was observed between women with gestational diabetes and pregnant controls. Plasma PAI-1 antigen levels were higher in gestational diabetes than pregnant and non-pregnant controls. Our study revealed that pregnancy was associated with elevated plasma TAFI antigen levels. However, no additional effect of gestational diabetes was found on plasma TAFI antigen ...Continue Reading

References

Nov 1, 1996·Thrombosis Research·P ComeglioR Abbate
Nov 28, 2001·British Journal of Haematology·P ChablozP de Moerloose
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Yasuko HoriYasuhiro Sumida
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Yutaka YanoYukihiko Adachi
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·H AubertM C Alessi
Mar 9, 2004·Gynecologic and Obstetric Investigation·Takashi WatanabeMitsuaki Suzuki
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Shannon M HeitritterEllen W Seely
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·D E Vaughan
Mar 2, 2006·Obstetrics and Gynecology·Heinz LeipoldChristof Worda
Apr 6, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marianne CoolmanFred C G J Sweep
Sep 9, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Gulay Sain GuvenTümay Sözen
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Sep 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Lynn P LoweUNKNOWN HAPO Study Cooperative Research Group
Jan 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ilknur Inegol GumusSema Sevgili
Jul 2, 2016·Journal of Laboratory Physicians·Suheyla GorarYalcin Aral
Mar 17, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Baris AkinciSena Yesil
May 26, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maritta Pöyhönen-AlhoRisto Kaaja
May 18, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eimer G O'MalleyMichael J Turner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Baris AkinciSena Yesil
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ilknur Inegol GumusSema Sevgili
© 2022 Meta ULC. All rights reserved