Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum

Microbiome
Mie Korslund Wiinblad CrusellOluf Pedersen

Abstract

Imbalances of gut microbiota composition are linked to a range of metabolic perturbations. In the present study, we examined the gut microbiota of women with gestational diabetes mellitus (GDM) and normoglycaemic pregnant women in late pregnancy and about 8 months postpartum. Gut microbiota profiles of women with GDM (n = 50) and healthy (n = 157) pregnant women in the third trimester and 8 months postpartum were assessed by 16S rRNA gene amplicon sequencing of the V1-V2 region. Insulin and glucose homeostasis were evaluated by a 75 g 2-h oral glucose tolerance test during and after pregnancy. Gut microbiota of women with GDM was aberrant at multiple levels, including phylum and genus levels, compared with normoglycaemic pregnant women. Actinobacteria at phylum level and Collinsella, Rothia and Desulfovibrio at genus level had a higher abundance in the GDM cohort. Difference in abundance of 17 species-level operational taxonomic units (OTUs) during pregnancy was associated with GDM. After adjustment for pre-pregnancy body mass index (BMI), 5 of the 17 OTUs showed differential abundance in the GDM cohort compared with the normoglycaemic pregnant women with enrichment of species annotated to Faecalibacterium and Anaerotruncus and...Continue Reading

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Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Mie Korslund Wiinblad CrusellOluf Pedersen

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Methods Mentioned

BETA
PCR
contraception
amplicon sequencing

Software Mentioned

vegan R
DESeq2 R package
DESeq2
UTAX
vsearch
DESeq2 R
R Studio
Cladogram
vegan R package
vegan

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