PMID: 9442806Jan 27, 1998Paper

Gestational diabetes mellitus and HLA class II (-DQ, -DR) association: The Digest Study

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
A VambergueP M Danze

Abstract

Gestational diabetes mellitus (GDM) and impaired glucose tolerance during pregnancy (IGT) are associated with an increased risk of perinatal morbidity and then further development of diabetes among 30-50% of affected women. This is a real public health problem that deserves investigation of phenotypic and genotypic predisposing markers. However, the involvement of genetic background in GDM and IGT remains unclear. In particular, association with HLA class II polymorphism has been poorly studied and has produced conflicting results. In attempt to clarify these discrepancies, we investigated HLA class II polymorphism in 95 GDM and 95 IGT women from the north of France using DNA amplification followed by restriction enzyme digestion (PCR-RFLP). Ninety-five pregnant women with normal glucose tolerance (NGT) were chosen as a control reference group. The distribution of HLA class II polymorphism was not found to be significantly different between GDM, IGT and NGT samples. In particular, we did not find any significant variation of DRB1*03 and DRB1*04 allele frequencies between these three groups. These data provide further evidence that insulin-dependent diabetes mellitus (IDDM) HLA class II susceptibility alleles cannot serve as gen...Continue Reading

Citations

Mar 11, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P AroviitaR Kekomäki
Jul 14, 2006·American Journal of Reproductive Immunology : AJRI·Andrea SteinbornEdgar Schmitt
Jun 16, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·A PapadopoulouUNKNOWN DiPiS Study Group
Jan 5, 2002·Diabetes/metabolism Research and Reviews·D Mauricio, A de Leiva
Feb 27, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A Ben-HaroushM Hod
May 22, 2010·The British Journal of Nutrition·Clive J Petry

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