Gestational diabetes mellitus is associated with increased leukocyte peroxisome proliferator-activated receptor γ expression

Archives of Medical Science : AMS
Marzena WójcikKatarzyna Cypryk

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor of the nuclear receptor superfamily that is involved in lipid and carbohydrate metabolism as well as inflammation; thereby it participates in metabolic diseases including diabetes. Although PPARγ expression has been observed in different tissues of diabetic patients, its level in leukocytes from subjects affected by gestational diabetes mellitus (GDM) has not yet been reported. This study aimed to investigate leukocyte PPARG expression in GDM patients at 24-33 weeks of gestation and, in turn, to correlate these alterations with anthropometric and metabolic parameters of patients. Leukocytes were isolated from the blood of normal glucose tolerant (NGT; n = 34) and GDM (n = 77) pregnant women between 24 and 33 weeks of gestation. Leukocyte PPARG mRNA expression was determined by semi-quantitative polymerase chain reaction. Univariate correlation analysis was performed to investigate associations between PPARG expression and clinical characteristics of patients. Leukocyte PPARG mRNA level was significantly higher in GDM than NGT women (p < 0.05). In the whole study group, PPARG expression positively correlated with plasma glucose concen...Continue Reading

Citations

Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Ricardo A L DE SousaJulia R Clarke
Sep 15, 2018·PloS One·Malgorzata Bukowiecka-MatusiakLucyna Alicja Wozniak

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Gelix One 220
Statistica

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