Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis

Journal of Hepatology
Ryan D SheldonR Scott Rector

Abstract

Mounting evidence indicates that maternal exercise confers protection to adult offspring against various diseases. Here we hypothesized that maternal exercise during gestation would reduce high-fat diet (HFD)-induced hepatic steatosis in adult rat offspring. Following conception, pregnant dams were divided into either voluntary wheel running exercise (GE) or wheel-locked sedentary (GS) groups throughout gestation (days 4-21). Post-weaning, offspring received either normal chow diet (CD; 10% fat, 70% carbohydrate, 20% protein) or HFD (45% fat, 35% carbohydrate, and 20% protein) until sacrificed at 4- or 8-months of age. GE did not affect offspring birth weight or litter size. HFD feeding in offspring increased weight gain, body fat percentage, and glucose tolerance test area under the curve (GTT-AUC). Male offspring from GE dams had reduced body fat percentage across all ages (p<0.05). In addition, 8-month male offspring from GE dams were protected against HFD-induced hepatic steatosis, which was associated with increased markers of hepatic mitochondrial biogenesis (PGC-1α and TFAM), autophagic potential (ATG12:ATG5 conjugation) and hepatic triacylglycerol secretion (MTTP). The current study provides the first evidence that gest...Continue Reading

References

Mar 27, 2001·The Journal of Cell Biology·N MizushimaT Yoshimori
Jul 9, 2004·Pediatric Research·Peter D Gluckman, Mark A Hanson
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Nov 8, 2007·The Journal of Biological Chemistry·Takao HanadaYoshinori Ohsumi
Jan 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·R Scott RectorJamal A Ibdah
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Aug 7, 2008·Journal of Hepatology·Janus P OngZobair M Younossi
Oct 11, 2008·Medicine and Science in Sports and Exercise·Katja M BorodulinAimee M Benson
Oct 30, 2008·Current Opinion in Lipidology·Mohammed Mahmood Hussain, Ahmed Bakillah
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Apr 22, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva Morán-SalvadorJoan Clària
May 14, 2011·Journal of Applied Physiology·R Scott Rector, John P Thyfault
May 2, 2012·Molecular and Cellular Biology·Danielle GlickKay F Macleod
Aug 18, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·E Matthew MorrisJamal A Ibdah
Aug 31, 2012·Autophagy·Hildegard I D MackSheila M Thomas
Aug 31, 2012·American Journal of Physiology. Endocrinology and Metabolism·Lindsay G CarterKevin J Pearson
Dec 19, 2012·Medicine and Science in Sports and Exercise·Lindsay G CarterKevin J Pearson
Apr 20, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Christopher D Byrne, Giovanni Targher
May 3, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria Z AlfaradhiSusan E Ozanne
Jun 21, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Ignacio G CamarilloSean Newcomer
Oct 28, 2014·The Journal of Clinical Investigation·David G CotterPeter A Crawford
Mar 21, 2015·Medicine and Science in Sports and Exercise·A Nicole BlaizeSean C Newcomer

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Citations

Jun 18, 2016·Nature Reviews. Endocrinology·Romain Barrès, Juleen R Zierath
Sep 1, 2016·Journal of Developmental Origins of Health and Disease·C S Rosenfeld
Apr 4, 2017·Acta Physiologica·J Denham
Jun 3, 2017·Diabetes·Kristin I StanfordLaurie J Goodyear
Jan 13, 2018·Gerontology·Joshua D PrestonKevin J Pearson
May 23, 2018·Medicine and Science in Sports and Exercise·Rory P CunninghamR Scott Rector
May 23, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mary P MooreR Scott Rector
Sep 11, 2019·Journal of Developmental Origins of Health and Disease·Marcella Martins TerraVera Maria Peters
Mar 19, 2020·Chinese Medical Journal·Jia ZhengXin-Hua Xiao
Sep 1, 2018·The Journal of Clinical Investigation·Peter R Baker, Jacob E Friedman
Jul 8, 2020·Journal of Developmental Origins of Health and Disease·Caroline Peres KleinCristiane Matté
Sep 16, 2020·Nature Metabolism·Joji KusuyamaLaurie J Goodyear
Jul 10, 2018·Molecular Neurobiology·Caroline Peres KleinCristiane Matté
Sep 24, 2020·Scientific Reports·Inga Bae-GartzEva Hucklenbruch-Rother
Feb 19, 2021·Nutrition·Renata TarevnicMarcia Barbosa Aguila
Feb 14, 2021·European Journal of Clinical Investigation·Jorge BelezaJosé Magalhães
May 11, 2020·Neuroscience·Pauline Maciel AugustCristiane Matté
Jun 14, 2021·European Journal of Clinical Investigation·Jelena Stevanović-SilvaJosé Magalhães
Sep 11, 2021·Journal of Developmental Origins of Health and Disease·Kristen M PlattKevin J Pearson
Apr 4, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·S VerdièreP Deruelle

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