Gestational exposure to nicotine and/or benzo[a]pyrene causes long-lasting neurobehavioral consequences

Birth Defects Research
Andrew B HawkeyEdward D Levin

Abstract

Tobacco smoke is a complex mixture that includes thousands of compounds. Previously, we have found that gestational exposure to the complex mixture of tobacco smoke extract caused long-term neurobehavioral impairments. In this study, we examined the interaction of two of the most biologically active, nicotine and benzo[a]pyrene (BaP). Developmental effects were determined in Sprague-Dawley rats prenatally exposed to low doses of BaP and nicotine (0.03 mg/kg/day of BaP and 2 mg/kg/day of nicotine) via maternal osmotic minipumps throughout gestation. Behavioral function was assessed in the offspring via a battery of tests through adolescence into adulthood. There were sex-selective effects in four of the behavioral tests. In the elevated plus maze, there was a significant interaction of BaP and sex, where BaP-treated males showed a trend for increased activity. In the novelty suppressed feeding test, there were significant sex selective effects in males such that the normal sex difference in the behavior in this test was eliminated. Male offspring with prenatal exposure to either nicotine or BaP showed significant reductions in fear response. In the Figure-8 locomotor activity test, BAP-exposed male offspring were significantly h...Continue Reading

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Citations

Apr 25, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Shu-Jing HuangYi-Ming Su
Aug 31, 2021·Archives of Environmental & Occupational Health·Makiko AriyoshiTakashi Yorifuji

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