Gestational exposure to particulate air pollution exacerbates the growth phenotypes induced by preconception paternal alcohol use: a multiplex model of exposure.

Environmental Epigenetics
Toriq A MustaphaMichael C Golding

Abstract

It is now clear that parental histories of drug use, toxicant exposure, and social stress all have a significant influence on the health and development of the next generation. However, the ability of epigenetic parental life memories to interact with subsequent gestational exposures and cumulatively modify the developmental trajectory of the offspring remains an unexplored perspective in toxicology. Studies from our laboratory have identified male-specific postnatal growth restriction in a mouse model of chronic, preconception paternal alcohol exposure. The goal of the current study was to determine if paternal alcohol use, before conception, could modify the susceptibility of the offspring to a completely separate exposure encountered by the mother during pregnancy. In independent experiments, we previously identified altered developmental programming and increased markers of severe asthma induced by gestational exposure to particulate air pollution. In this study, male mice were exposed to either the control or alcohol preconception treatments, then mated to naive females, which we subsequently exposed to an ultrafine mixture of particulate matter via inhalation. Individually, neither preconception paternal drinking nor gest...Continue Reading

References

Dec 31, 2002·JAMA : the Journal of the American Medical Association·Timothy S NaimiJames S Marks
Jul 17, 2007·Journal of Epidemiology and Community Health·Olivier LaurentClaire Segala
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ketan ShankardassKiros Berhane
Aug 1, 2012·Journal of Studies on Alcohol and Drugs·Megan E PatrickJohn E Schulenberg
Aug 16, 2014·Science·Michelle LaneSarah A Robertson
Nov 28, 2014·Advances in Experimental Medicine and Biology·Wendie S CohickTiffany A Katz
May 6, 2015·Chemical Reviews·Renyi ZhangYuan Wang
Jun 22, 2016·Annals of Global Health·Tongzhang ZhengKarl Kelsey
Oct 12, 2016·Cell and Tissue Research·Mariana Matera VerasPaulo Saldiva
Aug 18, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Richard C ChangMichael C Golding
Feb 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Kristal A RychlikNatalie M Johnson

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Citations

Oct 6, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jonathan C BehlenNatalie M Johnson

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