Gestational protein restriction alters cell proliferation in rat placenta

Journal of Molecular Histology
Hércules J RebelatoRosana Catisti

Abstract

We recently showed that gestational protein restriction (GPR) alters the structure of the rat placenta on day 19 of gestation (dG). The aim of the study was to investigate the spatial and temporal immunolocalization of proliferating cell antigen Ki67 in normal and GPR placental development. Pregnant Wistar rats were divided into two groups: normal (NP, 17 % casein) or low-protein diet (LP, 6 % casein). Placentas and fetus were collected and weighed at 15, 17, 19 and 21 dG. Morphological, morphometric and ultrastructural analyses were performed. Immunoperoxidase was used to identify nuclear antigen Ki67 in placental sections. We observed a significant reduction in the number of trophoblast giant cells and glycogen cells in the LP group. Placental weight was significantly reduced only at 17 dG in the LP group, in parallel to a decrease in glycogen cells. From 15 to 21 dG, the thickness of the junctional zone (JZ) decreased in NP and LP animals, while that of the labyrinth zone (LZ) increased in parallel to a reduction in the number of proliferating cells in this LZ zone. GPR significantly inhibits cell proliferation in the JZ, especially at 15 and 17 dG. The ultrastructural appearance of the cytoplasm of giant and cytotrophoblast...Continue Reading

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Citations

May 16, 2018·The British Journal of Nutrition·Qiongxian YanZhiliang Tan
Jan 22, 2018·Journal of Molecular Histology·Zhan ZhangLinlin Zhang
Jul 13, 2018·Frontiers in Physiology·Emily J CammAmanda N Sferruzzi-Perri
Apr 12, 2021·Seminars in Cancer Biology·Jing ZhangXinzhe Liu
Oct 27, 2020·Journal of Oral Biology and Craniofacial Research·Bruno CalsaMilton Santamaria

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