Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
J M JohnsMatthew S McMurray

Abstract

Cocaine administered chronically throughout gestation has been correlated with deficits in maternal behavior, increased maternal aggressive behavior and decreased oxytocin levels in rats. In addition to its effects on oxytocin levels, cocaine is a potent serotonergic, dopaminergic and noradrenergic reuptake inhibitor. Alterations in the dopaminergic and serotonergic systems have been suggested as possibly having a role in cocaine-induced maternal aggression. This study was in part, an attempt to understand some of the mechanisms by which cocaine increases postpartum aggression, particularly as they relate to changes in the oxytocin system. Oxytocin receptor number and binding affinity in the medial preoptic area of the hypothalamus, ventral tegmental area, hippocampus and amygdala were determined for lactating rat dams on postpartum day 6 (PPD 6) that were gestationally treated with cocaine, fluoxetine, saline or an amfonelic acid/fluoxetine drug combination. Cocaine and fluoxetine treatment both resulted in a significant up-regulation of oxytocin receptor number and lower receptor affinity in the amygdala of lactating rat dams compared to saline controls and the amfonelic acid/fluoxetine combination treatment group. Cocaine tr...Continue Reading

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Citations

May 8, 2013·Neuroscience and Biobehavioral Reviews·Jan G Veening, Berend Olivier
Mar 24, 2007·Developmental Psychobiology·Romana SlamberováRichard Rokyta
Nov 30, 2018·Surgical Neurology International·Ramsis F GhalyNebojsa Nick Knezevic
Nov 2, 2016·Behavioural Pharmacology·Jacinta L Johnson, Femke T A Buisman-Pijlman
Jul 9, 2008·Stress : the International Journal on the Biology of Stress·M S McMurrayJ M Johns
Jun 29, 2021·Frontiers in Cell and Developmental Biology·Talita BaptistaRodrigo Grassi-Oliveira

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