Gestational trophoblastic diseases: 2. Hyperglycosylated hCG as a reliable marker of active neoplasia

Gynecologic Oncology
Laurence A ColeErnest Kohorn

Abstract

To determine whether circulating hyperglycosylated human chorionic gonadotropin (hCG-H), a promoter of choriocarcinoma growth and tumorigenesis, is a reliable marker of active gestational trophoblastic neoplasia (GTN) or choriocarcinoma, and whether hCG-H can consistently discriminate quiescent gestational trophoblastic disease (GTD) from neoplasia. Patients were those referred to the USA hCG Reference Service for consultation. These included a total of 82 women with GTN, including 30 with histologic choriocarcinoma. They were compared with 26 patients with resolving hydatidiform mole and 69 with quiescent GTD (persistent positive low value of real hCG but no clinical evidence of disease). All were tested for total hCG and hCG-H. hCG-H was calculated as the percentage of total hCG (hCG-H(%)). We compared the utility of total hCG and hCG-H(%) in detecting active GTN and quiescent GTD. There was no significant difference when measuring total hCG (includes regular and hyperglycosylated hCG), between women with quiescent GTD and self-resolving hydatidiform mole compared to choriocarcinoma/GTN cases (P > 0.05 and P > 0.05). In contrast, hCG-H(%) was significantly higher in choriocarcinoma/GTN cases (P < 0.000001, and P < 0.000001). ...Continue Reading

Citations

Feb 18, 2014·Current Obstetrics and Gynecology Reports·Siew-Fei Ngu, Karen K L Chan
Jan 28, 2009·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
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Dec 27, 2011·Gynecologic Oncology·Laurence A Cole
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Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
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Feb 27, 2016·The Journal of Obstetrics and Gynaecology Research·Xue-Qian QianXiao-Yun Wan
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Jun 29, 2021·Therapeutic Advances in Reproductive Health·Oluwafunmilayo OyatogunDanny J Schust

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